Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies.
Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies.
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DOI：
10.1016/s1472-6483(10)60037-5
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发表时间：
2009-06
影响因子：
4
通讯作者：
Oehninger, Sergio
中科院分区：
文献类型：
--
作者：
Beydoun, Hind A.;Stadtmauer, Laurel;Beydoun, May A.;Russell, Helena;Zhao, Yueqin;Oehninger, Sergio
该研究的目的是检查多囊卵巢综合征（PCOS）和体重指数（BMI）对体外受精（IVF）或卵胞浆内单精子注射（ICSI）治疗成功的选定指标的影响。回顾性队列研究使用PCOS女性接受的69个IVF/ICSI治疗周期的现有数据和非PCOS女性在主要生育治疗中心接受的69个IVF/ICSI治疗周期的个体匹配样本进行。BMI（kg/m2）作为连续和分类（< 25，25 - 29.9 ≥ 30）变量进行分析。结果表明，PCOS与获卵数直接相关。无论PCOS状态如何，持续BMI与获得的卵母细胞总数和成熟卵母细胞数呈负相关。多元线性回归分析表明，PCOS或连续BMI对每个成熟卵母细胞获得或授精的成熟卵母细胞受精数没有显着影响。同样，多因素logistic回归分析表明，PCOS和连续BMI对妊娠、流产或活产的几率没有显著影响。此外，分类BMI并不影响IVF/ICSI治疗成功的过程和结局指标。PCOS和持续BMI似乎对IVF/ICSI治疗的早期阶段有显著和明显的影响，但对后期阶段没有影响。
The purpose of the study is to examine the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on selected indicators of in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment success. A retrospective cohort study was conducted using existing data on 69 IVF/ICSI treatment cycles undergone by PCOS women and an individually matched sample of 69 IVF/ICSI treatment cycles undergone by non-PCOS women at a major fertility treatment center. BMI (kg/m2) was analyzed as a continuous and categorical (< 25, 25−29.9 ≥ 30) variable. Results indicated that PCOS was directly associated with the number of oocytes retrieved. Irrespective of PCOS status, continuous BMI was inversely associated with total and mature oocytes retrieved. Multiple linear regression analyses indicated no significant effects of PCOS or continuous BMI on the number of mature oocytes fertilized per mature oocyte retrieved or inseminated. Similarly, multiple logistic regression analyses suggested no significant effect of PCOS and continuous BMI on the odds of pregnancy, miscarriage or live birth. Furthermore, categorical BMI did not influence process and outcome measures of IVF/ICSI treatment success. PCOS and continuous BMI appear to have significant and distinct effects on early stages but not on later stages of IVF/ICSI treatment.
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影响因子：
5.8
作者：
Knochenhauer, ES;Key, TJ;Azziz, R
通讯作者：
Azziz, R
影响因子：
6.1
作者：
Abdalla, H;Thum, MY
通讯作者：
Thum, MY
影响因子：
3.7
作者：
Beck-Peccoz P;Persani L
通讯作者：
Persani L
影响因子：
4
作者：
Matalliotakis, Ioannis;Cakmak, Hakan;Arici, Aydin
通讯作者：
Arici, Aydin
DOI：
10.1038/ncpendmet0117
发表时间：
2006-03-01
影响因子：
--
作者：
Azziz, Ricardo
通讯作者：
Azziz, Ricardo