Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.
Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.
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光敏剂胶束与 IDO 抑制剂一起增强癌症光热疗法和免疫疗法
DOI：
10.1002/advs.201700891
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Qian Z
中科院分区：
文献类型：
--
作者：
Peng J;Xiao Y;Li W;Yang Q;Tan L;Jia Y;Qu Y;Qian Z
光热疗法(PTT)的治疗效果仍然受到光的透明深度的阻碍。PTT与免疫疗法的结合为解决这一问题提供了策略。调节代谢相关酶是一种很有前途的刺激免疫反应的策略。在这里，一种具有光热转化和色氨酸代谢途径调节特性的纳米系统(NLG919/IR780胶束)被用来抑制有效PTT以外的肿瘤边缘的生长，促进肿瘤PTT和免疫治疗。结果表明，温和的热处理促进了肿瘤边缘的生长，而不是有效的PTT对热休克蛋白(HSP)、吲哚胺2，3-双加氧酶(IDO)和程序性死亡配体1(PD-L1)的上调。NLG919/IR780胶束能有效抑制IDO的活性，但不影响IDO的表达水平。NLG919/IR780胶束可以有效地在肿瘤内积聚，并可以迁移到淋巴结和淋巴系统。体内抗肿瘤研究表明，NLG919/IR780胶束能有效抑制原发肿瘤PTT后肿瘤边缘的生长。NLG919/IR780胶束介导的PTT和IDO抑制进一步刺激T淋巴细胞的激活，抑制远端肿瘤的生长(非内窥镜效应)。结果表明，NLG919/IR780胶束结合了PTT和免疫治疗，抑制了光热治疗后肿瘤边缘和远端肿瘤的生长。
The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth of light. Combining PTT with immunotherapy provides strategies to solve this problem. Regulating metabolism‐related enzymes is a promising strategy to stimulate immune response. Here, a nanosystem (NLG919/IR780 micelles) with the properties of photothermal conversion and regulation of the tryptophan metabolic pathway is used to suppress the growth of the tumor margin beyond effective PTT and promote tumor PTT and immunotherapy. It is revealed that mild heat treatment promotes the growth of the tumor margin beyond effective PTT for the upregulation of heat shock protein (HSP), indoleamine 2,3‐dioxygenase (IDO), and programmed death‐ligand 1 (PD‐L1). The NLG919/IR780 micelles can effectively inhibit the activity of IDO but do not affect the level of IDO expression. NLG919/IR780 micelles can effectively accumulate in the tumor and can migrate to lymph nodes and the lymphatic system. In vivo antitumor studies reveal that NLG919/IR780 micelles effectively suppress the growth of tumor margin following PTT in primary tumors. NLG919/IR780 micelle‐mediated PTT and IDO inhibition further stimulate the activation of T lymphocytes, inhibiting the growth of distal tumors (abscopal effect). The results demonstrate that the NLG919/IR780 micelles combine PTT and immunotherapy and suppress the tumor margin as well as distal tumor growth post photothermal therapy.
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影响因子：
30.5
作者：
Chang CH;Pearce EL
通讯作者：
Pearce EL
影响因子：
41.2
作者：
通讯作者：
--
影响因子：
38.3
作者：
Luo M;Wang H;Wang Z;Cai H;Lu Z;Li Y;Du M;Huang G;Wang C;Chen X;Porembka MR;Lea J;Frankel AE;Fu YX;Chen ZJ;Gao J
通讯作者：
Gao J
影响因子：
38.3
作者：
Min Y;Roche KC;Tian S;Eblan MJ;McKinnon KP;Caster JM;Chai S;Herring LE;Zhang L;Zhang T;DeSimone JM;Tepper JE;Vincent BG;Serody JS;Wang AZ
通讯作者：
Wang AZ
影响因子：
16.8
作者：
Munn DH;Mellor AL
通讯作者：
Mellor AL