Effects of prenatal opioid exposure on functional networks in infancy.
Effects of prenatal opioid exposure on functional networks in infancy.
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DOI：
10.1016/j.dcn.2021.100996
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发表时间：
2021-10
影响因子：
4.7
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Merhar SL;Jiang W;Parikh NA;Yin W;Zhou Z;Tkach JA;Wang L;Kline-Fath BM;He L;Braimah A;Vannest J;Lin W
产前阿片类药物暴露与神经发育改变和视觉问题（如斜视和眼球震颤）有关。这些变化背后的神经基础尚不清楚。静息状态功能连接核磁共振成像（rsfMRI）是一种先进且成熟的评估大脑网络的技术。很少有研究检查了产前阿片类药物暴露对婴儿静息状态网络连接的影响。在这项初步研究中，我们使用全脑连接组方法和基于种子的方法，对4-8周龄的阿片类药物暴露婴儿（n = 19）和对照组（n = 20）的网络连通性进行了表征。产前阿片类药物暴露与中间性中心性和连接长度分布的差异有关，每组特有的积极连接明显长于普通连接。阿片类药物暴露组的独特连接更多的是网络间连接，而对照组的独特连接和两组的共同连接更多的是网络内连接。阿片类药物暴露组的网络体积较小，尤其是初级视觉网络，但网络强度与对照组相似。由骰子相似指数决定的网络拓扑结构在组间存在差异，特别是在视觉和执行控制网络中。这些结果可能为与产前阿片类药物暴露相关的发育和视觉问题的神经基础提供见解。
Prenatal opioid exposure has been linked to altered neurodevelopment and visual problems such as strabismus and nystagmus. The neural substrate underlying these alterations is unclear. Resting-state functional connectivity MRI (rsfMRI) is an advanced and well-established technique to evaluate brain networks. Few studies have examined the effects of prenatal opioid exposure on resting-state network connectivity in infancy. In this pilot study, we characterized network connectivity in opioid-exposed infants (n = 19) and controls (n = 20) between 4–8 weeks of age using both a whole-brain connectomic approach and a seed-based approach. Prenatal opioid exposure was associated with differences in distribution of betweenness centrality and connection length, with positive connections unique to each group significantly longer than common connections. The unique connections in the opioid-exposed group were more often inter-network connections while unique connections in controls and connections common to both groups were more often intra-network. The opioid-exposed group had smaller network volumes particularly in the primary visual network, but similar network strength as controls. Network topologies as determined by dice similarity index were different between groups, particularly in visual and executive control networks. These results may provide insight into the neural basis for the developmental and visual problems associated with prenatal opioid exposure.
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影响因子：
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作者：
Honein, Margaret A.;Boyle, Coleen;Redfield, Robert R.
通讯作者：
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影响因子：
5.7
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影响因子：
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作者：
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通讯作者：
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