Dynamic functional connectivity: promise, issues, and interpretations.

Dynamic functional connectivity: promise, issues, and interpretations.
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动态功能连接:承诺,问题和解释。

DOI:
10.1016/j.neuroimage.2013.05.079
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发表时间:
2013-10-15
期刊:
影响因子:
5.7
通讯作者:
Chang C
Chang C
中科院分区:
医学1区
文献类型:
--
作者:
Hutchison RM;Womelsdorf T;Allen EA;Bandettini PA;Calhoun VD;Corbetta M;Della Penna S;Duyn JH;Glover GH;Gonzalez-Castillo J;Handwerker DA;Keilholz S;Kiviniemi V;Leopold DA;de Pasquale F;Sporns O;Walter M;Chang C

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大脑必须在多个时间尺度上动态地整合、协调和响应内部和外部刺激。功能磁共振成像对大脑活动的非侵入性测量极大地促进了我们对支持大脑功能这些基本特征的大规模功能组织的理解。从以前的静息态fMRI调查的结论是基于静态的功能连接(FC)的描述,只有最近的研究已经开始利用的时间内包含的信息丰富的功能自发BOLD FC。新出现的证据表明,动态FC指标可能会指数的变化,宏观神经活动模式的认知和行为的关键方面,但限制方面的分析和解释仍然存在。在这里,我们回顾最近的研究结果,方法上的考虑,神经和行为的相关性,以及未来的发展方向,在新兴领域的动态FC调查。
The brain must dynamically integrate, coordinate, and respond to internal and external stimuli across multiple time scales. Non-invasive measurements of brain activity with fMRI have greatly advanced our understanding of the large-scale functional organization supporting these fundamental features of brain function. Conclusions from previous resting-state fMRI investigations were based upon static descriptions of functional connectivity (FC), and only recently studies have begun to capitalize on the wealth of information contained within the temporal features of spontaneous BOLD FC. Emerging evidence suggests that dynamic FC metrics may index changes in macroscopic neural activity patterns underlying critical aspects of cognition and behavior, though limitations with regard to analysis and interpretation remain. Here, we review recent findings, methodological considerations, neural and behavioral correlates, and future directions in the emerging field of dynamic FC investigations.
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