Establishing a controlled hookworm human infection (CHHI) model for Africa: A report from the stakeholders meeting held in Lambaréné, Gabon, November 10-11, 2019.
Establishing a controlled hookworm human infection (CHHI) model for Africa: A report from the stakeholders meeting held in Lambaréné, Gabon, November 10-11, 2019.
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建立非洲受控钩虫人类感染（CHHI）模型：2019年11月10日至11日在加蓬兰巴雷内举行的利益相关者会议的报告。
DOI：
10.1186/s13690-021-00650-z
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发表时间：
2021-07-05
期刊：
影响因子：
--
通讯作者：
Agnandji ST
中科院分区：
文献类型：
--
作者：
Alabi A;Hussain M;Hoogerwerf MA;Mengome CN;Egesa M;Driciru E;Wammes LJ;Kruize YCM;Sartono E;Adegnika AA;Kremsner PG;Yazdanbakhsh M;Agnandji ST
钩虫是全球疾病负担的主要贡献者，感染人数超过2.3亿。它已被确定为可以通过大规模药物管理和其他有效干预措施控制甚至消除的被忽视的热带病之一。数学模型表明，钩虫只能通过疫苗消除。控制钩虫人类感染（CHHI）模型可以促进疫苗和药物的快速开发。作为在非洲建立CHHI的第一步，我们于2019年11月10日至11日在加蓬的Lamberene举行了一次利益相关者会议。讨论围绕着有关不同管理机构的作用;加强现有管理能力的必要性和立法的作用;制定加蓬特有的伦理准则，以管理控制下的人类感染研究;制定研究方案;考虑文化和社会特点;在整个方案执行过程中有关各方之间定期举行联合审查会议的必要性;参与者的补偿。此外，关于在加蓬引入钩虫HI的操作考虑因素包括使用当地钩虫株进行攻毒感染、当地生产攻毒材料的能力建设以及建立适当的质量保证程序。讲习班讨论了在加蓬成功实施生殖健康倡议的若干预期障碍。我们的目标是，本报告将激发人们对在撒哈拉以南非洲实施这一模式的兴趣。在线版本包含补充材料，可通过10.1186/s13690-021-00650-z获得。
Hookworm is a major contributor to worldwide disease burden with over 230 million people infected. It has been identified as one of the Neglected Tropical Diseases that can be controlled and even eliminated through mass drug administration and other effective interventions. Mathematical models have shown that hookworm can only be eliminated via a vaccine. Controlled Hookworm Human Infection (CHHI) models can facilitate rapid development of vaccines and drugs. As a first step towards the establishment of CHHI in Africa, we held a stakeholders meeting in Lamberene, Gabon from 10 to 11 November 2019. Discussions revolved around the roles of the different regulatory institutions concerned; the need to strengthen existing regulatory capacity and the role of legislation; creating Gabon-specific ethical guidelines to govern Controlled Human Infection (CHI) studies; development of a study protocol; consideration of cultural and social peculiarities; the need for regular joint review meetings between interested parties throughout the process of protocol implementation; and participant compensation. Moreover, operational considerations concerning the introduction of CHHI in Gabon include the use of the local strain of hookworm for the challenge infections, capacity building for the local production of challenge material, and the establishment of adequate quality assurance procedures. The workshop addressed several of the anticipated hurdles to the successful implementation of CHHI in Gabon. It is our aim that this report will stimulate interest in the implementation of this model in the sub-Saharan African setting. The online version contains supplementary material available at 10.1186/s13690-021-00650-z.
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影响因子：
3.8
作者：
Adriko M;Tinkitina B;Arinaitwe M;Kabatereine NB;Nanyunja M;M Tukahebwa E
通讯作者：
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影响因子：
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Russell, Philip K.
影响因子：
3.8
作者：
Soukhathammavong, Phonepasong Aye;Sayasone, Somphou;Odermatt, Peter
通讯作者：
Odermatt, Peter
人钩虫感染的全球经济和健康负担。
影响因子：
3.8
作者：
Bartsch SM;Hotez PJ;Asti L;Zapf KM;Bottazzi ME;Diemert DJ;Lee BY
通讯作者：
Lee BY
影响因子：
3.8
作者：
Brelsford JB;Plieskatt JL;Yakovleva A;Jariwala A;Keegan BP;Peng J;Xia P;Li G;Campbell D;Periago MV;Correa-Oliveira R;Bottazzi ME;Hotez PJ;Diemert D;Bethony JM
通讯作者：
Bethony JM