The Global Economic and Health Burden of Human Hookworm Infection.
The Global Economic and Health Burden of Human Hookworm Infection.
复制标题
人钩虫感染的全球经济和健康负担。
DOI：
10.1371/journal.pntd.0004922
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发表时间：
2016-09
影响因子：
3.8
通讯作者：
Lee BY
中科院分区：
文献类型：
--
作者：
Bartsch SM;Hotez PJ;Asti L;Zapf KM;Bottazzi ME;Diemert DJ;Lee BY
尽管人类钩虫感染在世界上许多国家高度流行，但其对全球经济和健康的影响尚不为人所知。如果不能更好地了解钩虫在世界范围内造成的经济负担，诸如资助者、政策制定者、疾病控制官员和干预措施制造商等决策者很难确定在钩虫控制方面投入多少时间、精力和资源。我们开发了一个计算模拟模型，从社会角度估计2016年每个国家、世卫组织区域和全球钩虫感染的经济和健康负担。在全球范围内，钩虫感染共导致2,126,280例残疾年（使用2004年残疾体重估计）和4,087,803例残疾年（使用2010年残疾体重估计）（不包括认知损伤结果）。包括认知损伤并没有显著增加全球范围内的DALYs。生产力损失总额因贫血的可能性和使用的计算方法而异，以人均国民总收入代替年薪，每年损失从75亿美元到1389亿美元不等，以最低工资代替年薪，每年损失从25亿美元到439亿美元不等。尽管钩虫被列为一种被忽视的热带病，但其造成的经济和健康负担超过了对轮状病毒等一些比钩虫受到相对更多关注的疾病公布的估计。此外，某些正在向高收入国家过渡的大国，如巴西和中国，仍然面临相当大的钩虫负担。我们的工作按国家、世卫组织区域和全世界量化了与钩虫感染相关的经济和健康负担。我们还根据年龄、各种成本计算方法对负担进行了评估，并对关键参数和有争议的参数进行了广泛的敏感性分析，以确定模型结果估计的稳健性。我们报告了2016年与钩虫感染相关的DALYs和随之而来的健康结果，并显示了不同的残疾权重和贫血可能性对估计的影响。此外，我们的研究确定了未来研究和数据收集的潜在目标。我们的结果为决策者提供了重要的信息。没有更好地了解钩虫在世界各地和不同国家的经济和健康负担，诸如资助者、政策制定者、疾病控制官员和干预措施制造商等决策者很难确定在钩虫控制方面投入多少时间、精力和资源。我们的研究结果也可以帮助决策者知道钩虫应该放在他们的优先列表上，并分配有限的资源。
Even though human hookworm infection is highly endemic in many countries throughout the world, its global economic and health impact is not well known. Without a better understanding of hookworm’s economic burden worldwide, it is difficult for decision makers such as funders, policy makers, disease control officials, and intervention manufacturers to determine how much time, energy, and resources to invest in hookworm control. We developed a computational simulation model to estimate the economic and health burden of hookworm infection in every country, WHO region, and globally, in 2016 from the societal perspective. Globally, hookworm infection resulted in a total 2,126,280 DALYs using 2004 disability weight estimates and 4,087,803 DALYs using 2010 disability weight estimates (excluding cognitive impairment outcomes). Including cognitive impairment did not significantly increase DALYs worldwide. Total productivity losses varied with the probability of anemia and calculation method used, ranging from $7.5 billion to $138.9 billion annually using gross national income per capita as a proxy for annual wages and ranging from $2.5 billion to $43.9 billion using minimum wage as a proxy for annual wages. Even though hookworm is classified as a neglected tropical disease, its economic and health burden exceeded published estimates for a number of diseases that have received comparatively more attention than hookworm such as rotavirus. Additionally, certain large countries that are transitioning to higher income countries such as Brazil and China, still face considerable hookworm burden. Our work quantifies the economic and health burden associated with hookworm infection by country, WHO region, and worldwide. We also evaluated the burden by age, various costing methodologies, and ran an extensive sensitivity analysis on key and debated parameters to determine the robustness of our model’s resulting estimates. We report the DALYs associated with hookworm infections with consequent health outcomes in 2016 and show the impact that varying disability weights and likelihoods of anemia have on the estimates. Additionally, our study identified potential targets for future studies and data collection. Our results provide important information for decision makers. Without a better understanding of the economic and health burden of hookworm worldwide and in different countries, it is difficult for decision makers such as funders, policy makers, disease control officials, and intervention manufacturers to determine how much time, energy, and resources to invest in hookworm control. Our results can also help decision makers know where hookworm should fall on their priority lists and allocate limited resources.
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影响因子：
3.3
作者：
Jardim-Botelho, Anne;Raff, Sophia;Gazzinelli, Maria Flavia
通讯作者：
Gazzinelli, Maria Flavia
影响因子：
4
作者：
Koukounari, Artemis;Estambale, Benson B. A.;Brooker, Simon
通讯作者：
Brooker, Simon
影响因子：
--
作者：
Brooker, S;Bethony, J;Hotez, PJ
通讯作者：
Hotez, PJ
DOI：
10.1016/0035-9203(92)90448-l
发表时间：
1992-01-01
影响因子：
2.2
作者：
BRADLEY, M;CHANDIWANA, SK;MEDLEY, GF
通讯作者：
MEDLEY, GF
影响因子：
13.7
作者：
Bleakley, Hoyt
通讯作者：
Bleakley, Hoyt