Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread.
Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread.
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淋巴管、淋巴结和免疫系统：癌症扩散的障碍和门户。
DOI：
10.1007/s10585-012-9520-2
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发表时间：
2012-10
影响因子：
4
通讯作者：
Morton DL
中科院分区：
文献类型：
--
作者：
Ferris RL;Lotze MT;Leong SP;Hoon DS;Morton DL
区域淋巴结转移是判断恶性肿瘤预后的最重要指标。一般而言，众所周知，癌症的发展是由基因决定的，从原发性肿瘤部位的微环境，通常通过SLN网关，到远处部位的进展。在大约20%的时间里，癌细胞可以直接通过血管系统扩散到远处。因此，一般而言，癌症进展与Hellman的谱理论一致，即从局部癌症生长发展为淋巴结和全身转移是一个渐进的过程。肿瘤微环境中的癌症增殖可能导致肿瘤异质性增加，这在达尔文意义上通过其在宿主内的进化而不断变化而进一步复杂化。了解肿瘤微环境中淋巴管生成和血管生成的分子过程对于癌细胞进入淋巴管和血管系统的初始步骤至关重要，从而可以开发合理的治疗方法来抑制特定转移途径的过程。本章阐述了肿瘤学、淋巴结转移和抗肿瘤免疫的作用。我们提出了新的免疫靶点在淋巴结转移，淋巴结的重要性作为一个转移前的小生境，和免疫相关蛋白作为转移的生物标志物。
Metastasis to the regional lymph node is the most important prognostic indicator for the outcomes of patients with sold cancer. In general, it is well recognized that cancer development is genetically determined with progression from the microenvironment of the primary tumor site, oftentimes via the SLN gateway, to the distant sites. In about 20 % of the time, the cancer cells may spread directly through the blood vascular system to the distant sites. Thus, in general, cancer progression is consistent with Hellman’s spectrum theory in that development of nodal and systemic metastasis from a localized cancer growth is a progressive process. Cancer proliferation within the tumor microenvironment may give rise to increased tumor heterogeneity, which is further complicated by its continuous change through its evolution within the host in a Darwinian sense. It is crucial to understand the molecular process of lymphangiogenesis and hemangiogenesis in the tumor microenvironment with respect to the initial steps of cancer cells entering into the lymphatic and vascular systems so that rational therapy can be developed to curb the process of specific routes of metastasis. This chapter elucidates the role of lymphatics, nodal metastasis and antitumor immunity. We present novel immune targets in nodal metastases, the importance of the lymph node as a pre-metastatic niche, and immune-related proteins as biomarkers of metastasis.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
6.2
作者：
Dillman, Robert O.;Aaron, Kenneth;McClure, Stephanie E.
通讯作者：
McClure, Stephanie E.
DOI：
10.1097/cji.0b013e3181b8f421
发表时间：
2010-01
期刊：
Journal of immunotherapy (Hagerstown, Md. : 1997)
影响因子：
--
作者：
Andrade Filho PA;López-Albaitero A;Gooding W;Ferris RL
通讯作者：
Ferris RL
影响因子：
45.3
作者：
HELLMAN, S
通讯作者：
HELLMAN, S
影响因子：
56.9
作者：
FREEMAN, GJ;GRIBBEN, JG;NADLER, LM
通讯作者：
NADLER, LM