Islet transplantation a decade later and strategies for filling a half-full glass.

Islet transplantation a decade later and strategies for filling a half-full glass.
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DOI:
10.2337/db09-1846
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发表时间:
2010-06
期刊:
影响因子:
7.7
通讯作者:
Robertson RP
Robertson RP
中科院分区:
医学1区
文献类型:
--
作者:
Robertson RP

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用于治疗 1 型糖尿病的 Alloislet 移植在过去十年的上半叶享有很高的声誉,但在下半叶受到青睐。在这篇文章中,我将简要回顾一下2000年至2010年该领域发表的文献,以总结经验教训,考虑该手术应该被视为部分成功还是部分失败,并提出未来改善同种异体胰岛移植结果的几种策略。最后,我希望对这一手术的进展以及如何应用它来建立 1 型糖尿病患者的胰岛素独立性给予积极的评价。
Alloislet transplantation for the treatment of type 1 diabetes enjoyed highly favorable status in the first half of the last decade but declined in favor during the second half. In this Perspective, I will briefly review the literature published in this area from 2000 to 2010 for the purposes of extracting lessons we have learned, considering whether the procedure should be deemed a partial success or a partial failure, and offering several strategies to improve alloislet transplantation outcomes in the future. In the end, I hope to strike a positive note about where this procedure is going, and how it will be applied to establish insulin independence in patients with type 1 diabetes.
DOI: 10.1056/nejm199003293221305
发表时间: 1990-03-29
影响因子: 158.5
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