Apoptosome structure, assembly, and procaspase activation.
Apoptosome structure, assembly, and procaspase activation.
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DOI：
10.1016/j.str.2013.02.024
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发表时间：
2013-04-02
期刊：
影响因子：
5.7
通讯作者：
Akey, Christopher W.
中科院分区：
文献类型：
--
作者：
Yuan, Shujun;Akey, Christopher W.
Apaf-1 like molecules assemble into a ring-like platform known as the apoptosome. This cell death platform then activates procaspases in the intrinsic cell death pathway. In this review, crystal structures of Apaf-1 monomers and CED-4 dimers have been combined with apoptosome structures, to provide insights into the assembly of cell death platforms from humans, nematodes and flies. In humans, caspase recognition domains of procaspase-9 and Apaf-1 interact with each other to form a CARD-CARD disk, which interacts with the platform to create an asymmetric proteolysis machine. The disk tethers multiple pc-9 catalytic domains to the platform to raise their local concentration and this leads to zymogen activation. These advances have now set the stage for further studies of this critical activation process on the apoptosome.
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