Enhancement by grapefruit juice of morphine antinociception.
Enhancement by grapefruit juice of morphine antinociception.
复制标题
柚子汁增强吗啡镇痛作用。
DOI：
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发表时间：
2008
影响因子：
2
通讯作者：
S. Yamada
中科院分区：
文献类型：
--
作者：
T. Okura;Tadahiro Ozawa;Yoshihiko Ito;M. Kimura;Y. Kagawa;S. Yamada
本研究的目的是观察大鼠摄入西柚汁对吗啡抗伤害性作用的影响。吗啡(30 mg/kg)的抗伤害性作用口服西柚汁(2毫升/只)可显著增强小鼠的致死性。此外，在吗啡耐受大鼠中检测了西柚汁的作用。吗啡重复给药(100 mg/kg，P.O.)给药5d后，抗伤害性感觉明显下降，提示吗啡耐受性的形成。在吗啡耐受大鼠中，口服西柚汁显著增强了吗啡的抗伤害性作用。为研究吗啡重复给药5d后的药代动力学，在大鼠颈静脉和脊髓鞘内植入微透析探头。反复使用吗啡后，大鼠血液和鞘内脑脊液中的吗啡浓度逐渐降低。西柚汁可显著提高吗啡耐受大鼠的吗啡血药浓度。这些结果表明，口服西柚汁可通过增加吗啡的肠道吸收来增强吗啡的抗伤害作用。
The aim of this study was to investigate the effect of grapefruit juice intake on the antinociception of morphine in rats. The antinociception of morphine (30 mg/kg, per os (p.o.)) was significantly enhanced by the oral administration of grapefruit juice (2 ml/rat). Further, the effect of grapefruit juice was examined in morphine-tolerant rats. The repeated administration of morphine (100 mg/kg p.o.) for 5 d caused a marked decrease in the antinociception, indicating the development of morphine-tolerance. In the morphine-tolerant rats, oral administration of grapefruit juice potentiated significantly the antinociceptive effect of morphine. To examine the pharmacokinetics of morphine after the repeated treatment with morphine for 5 d, microdialysis probes were implanted into the jugular vein and spinal intrathecal space in rats. The morphine concentrations in the blood and intrathecal cerebrospinal fluid (CSF) were gradually decreased by the repeated treatment with morphine. The grapefruit juice treatment significantly increased the blood concentration of morphine in morphine-tolerant rats. These results suggest that oral administration of grapefruit juice enhances the morphine antinociception by increasing the intestinal absorption of this agent.
DOI：
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发表时间：
1999-07
期刊：
Drug metabolism and disposition: the biological fate of chemicals
影响因子：
--
作者：
Stephen P. Letrent;G. Pollack;Kenneth R. Brouwer;Kim L. R. Brouwer
通讯作者：
Stephen P. Letrent;G. Pollack;Kenneth R. Brouwer;Kim L. R. Brouwer
影响因子：
4.4
作者：
Carew, LB;McMurtry, JP;Alster, FA
通讯作者：
Alster, FA
影响因子：
4.1
作者：
BOKKENHEUSER, VD;SHACKLETON, CHL;WINTER, J
通讯作者：
WINTER, J