Immunolocalization of interleukin-1α in rat mandibular molars and its enhancement after in vivo injection of epidermal growth factor
Immunolocalization of interleukin-1α in rat mandibular molars and its enhancement after in vivo injection of epidermal growth factor
复制标题
大鼠下颌磨牙白细胞介素1α的免疫定位及其体内注射表皮生长因子后的增强
作者：
G. Wise;F. Lin;L. Zhao
白细胞介素-1 α（IL-1α）在出生后0-12天大鼠下颌第一磨牙中的免疫组织化学定位显示，IL-1α蛋白定位于牙囊附近的上皮星状网。染色的星状网是最突出的在出生后的早期和出生后第11天缺席。在第0天向大鼠注射表皮生长因子，大大增加了星状网中白细胞介素-1 α的染色强度。表皮生长因子（Epidermal growth factor，EGF）可增强体外培养的星状网状细胞中白细胞介素1α（interleukin-1α，IL-1 α）的基因表达，提示EGF可增强星状网状细胞中IL-1α mRNA的翻译。反过来，白细胞介素-1 α可能对邻近星状网的牙囊细胞发挥作用，因为EGF也增强了培养的牙囊细胞中白细胞介素-1受体I型信使RNA的表达，并增强了其在体内的表达。鉴于EGF可刺激牙齿的早熟萌出，其刺激星状网中白细胞介素-1 α的合成可能是EGF启动一系列分子事件以发出牙齿萌出信号的机制。
Immunolocalization of interleukin-1α in the first mandibular molars of rats from day 0–12 postnatally showed that the protein was localized in the epithelial stellate reticulum adjacent to the dental follicle. Staining of the stellate reticulum was most prominent in the early days postnatally and was absent by postnatal day 11. Injection of epidermal growth factor into rats at day 0 greatly increased the intensity of the staining for interleukin-1α in the stellate reticulum. Epidermal growth factor (EGF) enhanced the gene expression of interleukin-1α in stellate reticulum cells in vitro, and this study suggests there is enhanced translation of interleukin-1α messenger RNA in the stellate reticulum following EGF injection. In turn, the interleukin-1α may exert its effect on the dental follicle cells adjacent to the stellate reticulum because EGF also enhanced expression of the interleukin-1 receptor type I messenger RNA in cultured dental follicle cells as well as enhancing its expression in vivo. In view of the fact that injection of EGF will stimulate precocious eruption of teeth, its stimulus of interleukin-1α synthesis in the stellate reticulum may be the mechanism by which EGF initiates a cascade of molecular events to signal the onset of tooth eruption.
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转化生长因子-β (TGF beta) 对人类单核细胞具有趋化性，并诱导其表达血管生成活性。
DOI：
10.1016/s0006-291x(88)80319-x
发表时间：
1988
影响因子：
3.1
作者：
Wiseman,DM;Polverini,PJ;Kamp,DW;Leibovich,SJ
通讯作者：
Leibovich,SJ
人胸腺上皮细胞产生白细胞介素1。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Le,PT;Tuck,DT;Dinarello,CA;Haynes,BF;Singer,KH
通讯作者：
Singer,KH
影响因子：
3
作者：
MARKS, SC;CAHILL, DR
通讯作者：
CAHILL, DR
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Massagué,J
通讯作者：
Massagué,J
静止和增殖成纤维细胞中巨噬细胞集落刺激因子的基因表达和释放。
DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Falkenburg,JH;Harrington,MA;Walsh,WK;Daub,R;Broxmeyer,HE
通讯作者：
Broxmeyer,HE