Myoglobin expression: early induction and subsequent modulation of myoglobin and myoglobin mRNA during myogenesis
Myoglobin expression: early induction and subsequent modulation of myoglobin and myoglobin mRNA during myogenesis
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肌红蛋白表达：肌生成过程中肌红蛋白和肌红蛋白 mRNA 的早期诱导和后续调节
DOI：
10.1128/mcb.6.12.4539-4547.1986
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发表时间：
1986
影响因子：
5.3
通讯作者：
A. Jeffreys
中科院分区：
文献类型：
--
作者：
P. Weller;M. Price;H. Isenberg;Y. Edwards;A. Jeffreys
我们发现，肌红蛋白基因转录和肌红蛋白的外观发生在肌生成的早期，在人类和小鼠。与收缩蛋白基因相反，在后来的肌肉发育过程中，肌红蛋白mRNA和蛋白质水平随后增加了50至100倍。肌红蛋白和肌红蛋白mRNA在胎儿心脏中以升高的水平存在，并且在成人平滑肌中也以低水平检测到。在高度肌红蛋白化的海豹肌肉中，肌红蛋白mRNA的绝对水平非常高[占poly（A）+RNA总群体的2.8%]。海豹骨骼肌和各种人类肌肉类型中的肌红蛋白水平似乎由肌红蛋白mRNA库的大小决定。相反，小鼠骨骼肌中肌红蛋白的低水平与肌红蛋白mRNA的低水平没有明显的相关性。正如从胚胎骨骼肌中肌红蛋白mRNA的早期出现所预期的，大鼠和小鼠胚胎成肌细胞在体外融合和分化时都积累肌红蛋白mRNA。
We showed that myoglobin gene transcription and the appearance of myoglobin occur very early in myogenesis, in both humans and mice. In contrast to the contractile protein genes, there is a subsequent increase of 50- to 100-fold in myoglobin mRNA and protein levels during later muscle development. Myoglobin and myoglobin mRNA are present at elevated levels in fetal heart and are also detectable at low levels in adult smooth muscle. The absolute level of myoglobin mRNA in highly myoglobinized seal muscle is very high [2.8% of the total population of poly(A)+ RNAs]. Levels of myoglobin in seal skeletal muscle and in various human muscle types appear to be determined by the size of the myoglobin mRNA pool. In contrast, low levels of myoglobin in mouse skeletal muscle are not apparently correlated with low levels of myoglobin mRNA. As expected from the early appearance of myoglobin mRNA in embryonic skeletal muscle, both rat and mouse embryonic myoblasts accumulate myoglobin mRNA on fusion and differentiation in vitro.
组织限制性和阶段特异性转录维持在鸡 α-骨骼肌动蛋白基因 5 端侧翼的 411 个核苷酸内。
影响因子：
14.9
作者：
Grichnik,JM;Bergsma,DJ;Schwartz,RJ
通讯作者：
Schwartz,RJ