Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women.
Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women.
复制标题
肥胖和 2 型糖尿病与年轻女性 PCSK9 水平升高有关。
DOI：
10.1111/pedi.12490
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发表时间：
2017-12
影响因子：
3.4
通讯作者：
Biddinger SB
中科院分区：
文献类型：
--
作者：
Levenson AE;Shah AS;Khoury PR;Kimball TR;Urbina EM;de Ferranti SD;Maahs DM;Dolan LM;Wadwa RP;Biddinger SB
前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK 9）是低密度脂蛋白（LDL）胆固醇和心血管疾病（CVD）风险的关键调节因子，是一种新兴的治疗靶点。我们比较了有和没有2型糖尿病的年轻人的血清PCSK 9水平。在2005年至2010年期间，在俄亥俄州辛辛那提的一个年龄为15至26岁的队列中进行了横断面分析。在94名2型糖尿病青年、93名肥胖对照组和99名瘦对照组中测定了血清PCSK 9水平。进行相关性分析以确定各组和性别的PCSK 9的显著协变量，并使用多变量线性回归模型研究PCSK 9的独立决定因素。在女性中，肥胖和2型糖尿病受试者中的PCSK 9水平相对于瘦对照组显著升高（P < 0.01）。此外，PCSK 9与女性的多个代谢参数呈正相关：体重指数（BMI）、收缩压（SBP）、空腹血糖、空腹胰岛素和C反应蛋白（CRP）水平（P≤ 0. 02）。在男性中，与女性相比，PCSK 9水平总体降低（P=0.03），并且在瘦型、肥胖型或2型糖尿病组之间没有差异。肥胖和2型糖尿病与年轻女性中PCSK 9水平显著升高相关，但与年轻男性无关。这些数据表明，性别可以改变肥胖和糖尿病对年轻人PCSK 9的影响。
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein (LDL) cholesterol and cardiovascular disease (CVD) risk, and is an emerging therapeutic target. We compared serum PCSK9 levels in young adults, with and without type 2 diabetes. Cross-sectional analysis was conducted in a cohort, aged 15 to 26 years, in Cincinnati, OH, from 2005 to 2010. Serum PCSK9 levels were measured in 94 youth with type 2 diabetes, 93 obese control subjects, and 99 lean control subjects. Correlative analyses were conducted to determine significant covariates of PCSK9 by group and sex, and multivariate linear regression models were used to study the independent determinants of PCSK9. In females, PCSK9 levels were significantly increased in the obese and type 2 diabetes subjects relative to the lean controls (P < 0.01). Moreover, PCSK9 was positively correlated with multiple metabolic parameters in females: body mass index (BMI), systolic blood pressure (SBP), fasting glucose, fasting insulin, and C-reactive protein (CRP) levels (P≤0.02). In males, PCSK9 levels were decreased overall compared to females (P=0.03), and did not differ between the lean, obese, or type 2 diabetes groups. Obesity and type 2 diabetes were associated with significantly higher levels of PCSK9 in young women, but not in young men. These data suggest that sex could modify the effects of obesity and diabetes on PCSK9 in young adults.
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影响因子：
5.3
作者：
Kappelle, Paul J. W. H.;Lambert, Gilles;Dullaart, Robin P. F.
通讯作者：
Dullaart, Robin P. F.
影响因子：
5.1
作者：
Kershnar, Ann K.;Daniels, Stephen R.;Rodriguez, Beatriz L.
通讯作者：
Rodriguez, Beatriz L.
影响因子：
4.5
作者：
Mayne J;Dewpura T;Raymond A;Cousins M;Chaplin A;Lahey KA;Lahaye SA;Mbikay M;Ooi TC;Chrétien M
通讯作者：
Chrétien M
影响因子：
5.8
作者：
Lakoski, Susan G.;Lagace, Thomas A.;Hobbs, Helen H.
通讯作者：
Hobbs, Helen H.
DOI：
10.1161/01.atv.0000204337.81286.1c
发表时间：
2006-05-01
影响因子：
8.7
作者：
Berge, KE;Ose, L;Leren, TP
通讯作者：
Leren, TP