Low metabolic activity in primary gastric adenocarcinoma is associated with resistance to chemoradiation and the presence of signet ring cells.
Low metabolic activity in primary gastric adenocarcinoma is associated with resistance to chemoradiation and the presence of signet ring cells.
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DOI：
10.1007/s00595-020-02018-2
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发表时间：
2020-10
期刊：
影响因子：
2.5
通讯作者：
Ajani, Jaffer A.
中科院分区：
文献类型：
--
作者：
Harada, Kazuto;Patnana, Madhavi;Wang, Xuemei;Iwatsuki, Masaaki;Murphy, Mariela A. Blum;Zhao, Meina;Das, Prajnan;Minsky, Bruce D.;Weston, Brian;Lee, Jeffrey H.;Bhutani, Manoop S.;Estrella, Jeannelyn S.;Shanbhag, Namita;Ikoma, Naruhiko;Badgwell, Brian D.;Ajani, Jaffer A.
关键词：
术前放化疗是局限性胃腺癌（GAC）的一种潜在治疗选择。目前，对放化疗的反应无法预测。我们分析了治疗前的最大标准化摄取值（SUVmax）和总病变糖酵解（TLG）的正电子发射断层扫描/计算机断层扫描作为潜在的预测因素的反应，放化疗。我们分析了59例接受术前放化疗的GAC患者的SUVmax和TLG数据。我们使用逻辑回归模型预测病理完全缓解（pCR）和Kaplan-Meier曲线确定高和低SUVmax或TLG患者的总生存期。29例患者（49%）患有Siewert III型腺癌，30例（51%）肿瘤位于胃下部。41例患者有低分化的GAC，26例有印戒细胞。中位SUVmax为7.3（范围0-28.2），中位TLG为56.6（范围0-1881.5）。印戒细胞患者pCR率低，SUVmax和TLG也低。在多变量logistic回归模型中，高SUVmax是pCR的预测因子（比值比= 11.1，95%置信区间= 2.12-50.0，p = 0.004）。总生存率与SUVmax（对数秩p = 0.69）或TLG（对数秩p = 0.85）无关。高SUVmax与GAC中对放化疗和pCR的敏感性相关，印戒细胞似乎赋予耐药性。
Preoperative chemoradiation is a potential treatment option for localized gastric adenocarcinoma (GAC). Currently, the response to chemoradiation cannot be predicted. We analyzed the pretreatment maximum standardized uptake value (SUVmax) and total lesion glycolysis (TLG) on positron emission tomography/computed tomography as potential predictors of the response to chemoradiation. We analyzed the SUVmax and TLG data from 59 GAC patients who received preoperative chemoradiation. We used logistic regression models to predict a pathologic complete response (pCR) and Kaplan-Meier curves to determine overall survival among patients with high and low SUVmax or TLG. Twenty-nine patients (49%) had Siewert type III adenocarcinoma and 30 (51%) had tumors located in the lower stomach. Forty-one patients had poorly differentiated GAC, and 26 had signet ring cells. The median SUVmax was 7.3 (range 0–28.2) and the median TLG was 56.6 (range 0–1881.5). Patients with signet ring cells had a low pCR rate, as well as a low SUVmax and TLG. In the multivariable logistic regression model, high SUVmax was a predictor of pCR (odds ratio = 11.1, 95% confidence interval = 2.12–50.0, p = 0.004). Overall survival was not associated with the SUVmax (log-rank p = 0.69) or TLG (log-rank p = 0.85) A high SUVmax was associated with sensitivity to chemoradiation and pCR in GAC, and signet ring cells seemed to confer resistance.
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影响因子：
2.9
作者：
Amin, Mona A.;El-Shahat, Marwa E.;Obaia, Eman
通讯作者：
Obaia, Eman
影响因子：
45.3
作者：
Ajani, JA;Mansfield, PF;Gunderson, LL
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Gunderson, LL
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20.4
作者：
Erasmus, Jeremy J.;Munden, Reginald F.;Swisher, Stephen G.
通讯作者：
Swisher, Stephen G.
影响因子：
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作者：
Elimova, Elena;Slack, Rebecca S.;Ajani, Jaffer A.
通讯作者：
Ajani, Jaffer A.
DOI：
10.1007/s00432-010-0852-5
发表时间：
2010-12-01
影响因子：
3.6
作者：
Chung, Hyun Woo;Lee, Eun Jeong;Lee, Kyung-Yung
通讯作者：
Lee, Kyung-Yung