BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis.
BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis.
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DOI：
10.1016/j.jtho.2017.10.006
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Jones DR
中科院分区：
文献类型：
--
作者：
Bucciarelli PR;Tan KS;Chudgar NP;Brandt W;Montecalvo J;Eguchi T;Liu Y;Aly R;Travis WD;Adusumilli PS;Jones DR
乳腺癌转移抑制因子1（BRMS1）在非小细胞肺癌细胞和肿瘤中的表达降低。我们假设肿瘤内BRMS1表达与肺腺癌（LUAD）组织学亚型以及接受早期LUAD切除术患者的总生存期（OS）和无病生存期（DFS）相关。
确定了1030例接受了完全切除且有组织可供组织学评估的LUAD患者。构建组织微阵列，进行免疫染色并对BRMS1表达强度进行评分。估计总生存期和无病生存期（采用卡普兰 - 迈耶方法），并在组间进行比较（对数秩检验），按分期分层。使用单变量和多变量考克斯比例风险模型估计死亡和复发风险的风险比（HRs）。创建了总生存期和无病生存期列线图，并检验了模型性能。
肿瘤内BRMS1高表达的患者有632例（61%），低表达的患者有398例（39%）。BRMS1低表达与更高的病理T分期（P = 0.001）、更大的肿瘤大小（P≤0.0001）、更严重的淋巴管（P = 0.032）和血管（P = 0.001）侵犯、LUAD组织学亚型（P = 0.001）以及中、高肿瘤结构分级（P = 0.003）相关。BRMS1低表达是总生存期更差（HR，1.35 [95%置信区间，1.10 - 1.65]；P = 0.004）和无病生存期更差（HR，1.27 [95%置信区间，1.05 - 1.54]；P = 0.012）的独立预测因子。基于区分度和校准，总生存期和无病生存期列线图显示出良好的预测性能。
在接受手术切除的LUAD患者中，肿瘤内BRMS1低表达患者的总生存期和无病生存期明显更差。我们的研究结果表明，BRMS1是在手术切除的LUAD中具有预后意义的独立生物标志物。
Expression of breast cancer metastasis suppressor 1 (BRMS1) is decreased in non–small cell lung cancer cells and tumors. We hypothesized that intratumoral BRMS1 expression is associated with lung adenocarcinoma (LUAD) histologic subtypes and overall survival (OS) and disease-free survival (DFS) in patients undergoing resection for early-stage LUAD. Patients (n=1030) who underwent complete resection for LUAD with tissue available for histologic evaluation were identified. Tissue microarrays were constructed, and immunostaining was performed and scored for intensity of BRMS1 expression. OS and DFS were estimated (Kaplan-Meier method) and compared between groups (log-rank test), stratified by stage. Hazard ratios (HRs) for hazard of death and recurrence were estimated using univariable and multivariable Cox proportional hazards models. OS and DFS nomograms were created, and model performance was examined. Intratumoral BRMS1 expression was high in 632 (61%) and low in 398 (39%) patients. Low BRMS1 expression was associated with higher pathologic T stage (P=0.001), larger tumor size (P≤0.0001), greater lymphatic (P=0.032) and vascular (P=0.001) invasion, LUAD histologic subtypes (P=0.001), and intermediate and high architectural tumor grade (P=0.003). Low BRMS1 expression was an independent predictor of worse OS (HR, 1.35 [95% CI, 1.10–1.65]; P=0.004) and DFS (HR, 1.27 [95% CI, 1.05–1.54]; P=0.012). OS and DFS nomograms showed excellent predictive performance based on discrimination and calibration. Among patients with surgically resected LUAD, OS and DFS were significantly worse in low intratumoral BRMS1 expression. Our findings suggest BRMS1 is an independent biomarker with prognostic significance in surgically resected LUAD.
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影响因子：
6.2
作者：
Kadota, Kyuichi;Nitadori, Jun-ichi;Sarkaria, Inderpal S.;Sima, Camelia S.;Jia, Xiaoyu;Yoshizawa, Akihiko;Rusch, Valerie W.;Travis, William D.;Adusumilli, Prasad S.
通讯作者：
Adusumilli, Prasad S.
影响因子：
4
作者：
Samant, RS;Seraj, MJ;Welch, DR
通讯作者：
Welch, DR
影响因子：
20.4
作者：
Goldstraw, Peter;Chansky, Kari;Bolejack, Vanessa
通讯作者：
Bolejack, Vanessa
影响因子：
--
作者：
Eguchi T;Kadota K;Chaft J;Evans B;Kidd J;Tan KS;Dycoco J;Kolquist K;Davis T;Hamilton SA;Yager K;Jones JT;Travis WD;Jones DR;Hartman AR;Adusumilli PS
通讯作者：
Adusumilli PS
DOI：
10.1348/000711006x126600
发表时间：
2008-05-01
影响因子：
2.6
作者：
Gwet, Kilem Li
通讯作者：
Gwet, Kilem Li