Meiotic control of the APC/C: similarities & differences from mitosis.
Meiotic control of the APC/C: similarities & differences from mitosis.
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DOI：
10.1186/1747-1028-6-16
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发表时间：
2011-08-01
期刊：
影响因子：
2.3
通讯作者：
Strich R
中科院分区：
文献类型：
--
作者：
Cooper KF;Strich R
后期促进复合物是一种高度保守的E3连接酶复合物，在有丝分裂和减数分裂期间介导关键调控蛋白的破坏。为了保持倍性，这种破坏必须在调节蛋白执行其功能之后发生。因此，APC/C活性本身的调节对于在所有类型的细胞分裂期间维持倍性至关重要。在有丝分裂细胞分裂过程中，两个保守的激活蛋白Cdc 20和Cdh 1是APC/C激活和底物选择所必需的。然而，显着较少知道这些蛋白质如何调节APC/C活性在专门的减数分裂核分裂。此外，芽殖酵母和果蝇都利用第三种减数分裂特异性激活剂。在酿酒酵母中，这种减数分裂特异性激活剂被称为Ama 1。本文综述了Cdc 20和Ama 1如何协调APC/C活性来调节酵母减数分裂核分裂的知识。
The anaphase promoting complex is a highly conserved E3 ligase complex that mediates the destruction of key regulatory proteins during both mitotic and meiotic divisions. In order to maintain ploidy, this destruction must occur after the regulatory proteins have executed their function. Thus, the regulation of APC/C activity itself is critical for maintaining ploidy during all types of cell divisions. During mitotic cell division, two conserved activator proteins called Cdc20 and Cdh1 are required for both APC/C activation and substrate selection. However, significantly less is known about how these proteins regulate APC/C activity during the specialized meiotic nuclear divisions. In addition, both budding yeast and flies utilize a third meiosis-specific activator. In Saccharomyces cerevisiae, this meiosis-specific activator is called Ama1. This review summarizes our knowledge of how Cdc20 and Ama1 coordinate APC/C activity to regulate the meiotic nuclear divisions in yeast.
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影响因子：
16
作者：
Mallory, Michael J.;Cooper, Katrina F.;Strich, Randy
通讯作者：
Strich, Randy
影响因子：
1.5
作者：
Chu, T;Henrion, G;Strickland, S
通讯作者：
Strickland, S
DOI：
10.1073/pnas.94.26.14361
发表时间：
1997-12-23
影响因子：
11.1
作者：
Cohen-Fix, O;Koshland, D
通讯作者：
Koshland, D
影响因子：
3.3
作者：
Kramer, ER;Scheuringer, N;Peters, JM
通讯作者：
Peters, JM
DOI：
10.1073/pnas.250351297
发表时间：
2000-12-19
影响因子：
11.1
作者：
Cooper, KF;Mallory, MJ;Strich, R
通讯作者：
Strich, R