Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish.
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish.
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DOI：
10.1083/jcb.201203154
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发表时间：
2012-10-15
期刊：
影响因子：
--
通讯作者：
Huttenlocher A
中科院分区：
文献类型：
--
作者：
Yoo SK;Freisinger CM;LeBert DC;Huttenlocher A
Redox, SFK, and calcium signaling are immediate “wound signals” that integrate early wound responses and late epimorphic regeneration. Tissue injury can lead to scar formation or tissue regeneration. How regenerative animals sense initial tissue injury and transform wound signals into regenerative growth is an unresolved question. Previously, we found that the Src family kinase (SFK) Lyn functions as a redox sensor in leukocytes that detects H2O2 at wounds in zebrafish larvae. In this paper, using zebrafish larval tail fins as a model, we find that wounding rapidly activated SFK and calcium signaling in epithelia. The immediate SFK and calcium signaling in epithelia was important for late epimorphic regeneration of amputated fins. Wound-induced activation of SFKs in epithelia was dependent on injury-generated H2O2. A SFK member, Fynb, was responsible for fin regeneration. This work provides a new link between early wound responses and late regeneration and suggests that redox, SFK, and calcium signaling are immediate “wound signals” that integrate early wound responses and late epimorphic regeneration.
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影响因子：
16
作者：
Cabodi, S;Calautti, E;Dotto, GP
通讯作者：
Dotto, GP
影响因子：
5.3
作者：
Giannoni, E;Buricchi, F;Chiarugi, P
通讯作者：
Chiarugi, P
影响因子：
11.8
作者：
Knopf, Franziska;Hammond, Christina;Weidinger, Gilbert
通讯作者：
Weidinger, Gilbert
了解动物的组织再生能力和机制的进步。
DOI：
10.1038/nrg2879
发表时间：
2010-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.8
作者：
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通讯作者：
Tanguay, Robert L.