Advances in understanding tissue regenerative capacity and mechanisms in animals.

Advances in understanding tissue regenerative capacity and mechanisms in animals.
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了解动物的组织再生能力和机制的进步。

DOI:
10.1038/nrg2879
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发表时间:
2010-10
期刊:
Nature reviews. Genetics
影响因子:
--
通讯作者:
--
中科院分区:
其他
文献类型:
--
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关于组织再生如何以及为什么发生的问题吸引了无数生物学家,生物医学工程师和临床医生的注意。再生能力在器官和生物体之间差异很大,并且研究了具有不同技术优势和再生策略的一系列模型系统。自然再生事件中常见的几个关键问题正在从改进模型和方法中获得新的关注,包括:再生能力的确定;干细胞,去分化和转分化的重要性;再生信号如何启动和靶向;以及控制再生增殖和模式化的机制。
Questions about how and why tissue regeneration occurs capture the attention of countless biologists, biomedical engineers, and clinicians. Regenerative capacity differs greatly across organs and organisms, and a spectrum of model systems with different technical advantages and regenerative strategies are studied. Several key issues common to natural regenerative events are receiving new attention from improving models and approaches, including: the determination of regenerative capacity; the importance of stem cells, dedifferentation and transdifferentiation; how regenerative signals are initiated and targeted; and the mechanisms that control regenerative proliferation and patterning.
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发表时间: 1976-01-01
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