Mitochondrial depolarization and electrophysiological changes during ischemia in the rabbit and human heart.
Mitochondrial depolarization and electrophysiological changes during ischemia in the rabbit and human heart.
复制标题
兔子和人心脏缺血期间的线粒体去极化和电生理变化。
DOI：
10.1152/ajpheart.00437.2014
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Efimov,IgorR
中科院分区：
文献类型：
--
作者：
Sulkin,MatthewS;Boukens,BasJ;Tetlow,Megan;Gutbrod,SarahR;Ng,FuSiong;Efimov,IgorR
Instability of the inner mitochondrial membrane potential (ΔΨm) has been implicated in electrical dysfunction, including arrhythmogenesis during ischemia-reperfusion. Monitoring ΔΨmhas led to conflicting results, where depolarization has been reported as sporadic and as a propagating wave. The present study was designed to resolve the aforementioned difference and determine the unknown relationship between ΔΨmand electrophysiology. We developed a novel imaging modality for simultaneous optical mapping of ΔΨmand transmembrane potential (Vm). Optical mapping was performed using potentiometric dyes on preparations from 4 mouse hearts, 14 rabbit hearts, and 7 human hearts. Our data showed that during ischemia, ΔΨmdepolarization is sporadic and changes asynchronously with electrophysiological changes. Spatially, ΔΨmdepolarization was associated with action potential duration shortening but not conduction slowing. Analysis of focal activity indicated that ΔΨmis not different within the myocardium where the focus originates compared with normal ventricular tissue. Overall, our data suggest that during ischemia, mitochondria maintain their function at the expense of sarcolemmal electrophysiology, but ΔΨmdepolarization does not have a direct association to ischemia-induced arrhythmias.
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DOI：
10.1016/j.biocel.2009.02.016
发表时间：
2009-10
影响因子：
4
作者：
Aon, M. A.;Cortassa, S.;Akar, F. G.;Brown, D. A.;Zhou, L.;O'Rourke, B.
通讯作者：
O'Rourke, B.
谷胱甘肽氧化诱导的心律不齐可以通过预防线粒体去极化来抑制。
影响因子：
5
作者：
Brown, David A.;Aon, Miguel A.;Frasier, Chad R.;Sloan, Ruben C.;Maloney, Andrew H.;Anderson, Ethan J.;O'Rourke, Brian
通讯作者：
O'Rourke, Brian
代谢综合征患者术后心律失常是否是线粒体功能障碍的征兆？
影响因子：
24
作者：
David A. Brown;F. Moukdar
通讯作者：
F. Moukdar
影响因子：
5
作者：
Lyon AR;Joudrey PJ;Jin D;Nass RD;Aon MA;O'Rourke B;Akar FG
通讯作者：
Akar FG
影响因子：
4.8
作者：
Nicholls, David G.
通讯作者：
Nicholls, David G.