BMP signaling in vascular development and disease.

BMP signaling in vascular development and disease.
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DOI:
10.1016/j.cytogfr.2010.06.001
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发表时间:
2010-08
影响因子:
13
通讯作者:
de Caestecker, Mark P.
de Caestecker, Mark P.
中科院分区:
医学2区
文献类型:
--
作者:
Lowery, Jonathan W.;de Caestecker, Mark P.

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遗传和功能研究表明,骨形态发生蛋白(BMP)信号通路的共同组分在调节胚胎血管发育和促进成人血管稳态和疾病中发挥关键作用。然而,在体外和体内的研究结果之间的差异,和不同的功能特性的BMP信号通路在不同的血管床,导致争议的领域,一直难以调和。本文试图澄清这些问题,提供了一个最新的生物学和遗传学的BMP信号相关的完整的血管系统的概述。
Genetic and functional studies indicate that common components of the Bone Morphogenetic Protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo, and in promoting vascular homeostasis and disease in the adult. However, discrepancies between in vitro and in vivo findings, and distinct functional properties of the BMP signaling pathway in different vascular beds have led to controversies in the field that have been difficult to reconcile. This review attempts to clarify some of these issues by providing an up to date overview of the biology and genetics of BMP signaling relevant to the intact vasculature.
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