The origin and diversification of the merozoite surface protein 3 (msp3) multi-gene family in Plasmodium vivax and related parasites.
The origin and diversification of the merozoite surface protein 3 (msp3) multi-gene family in Plasmodium vivax and related parasites.
复制标题
DOI：
10.1016/j.ympev.2014.05.013
复制
发表时间：
2014-09
影响因子：
4.1
通讯作者：
Escalante, Ananias A.
中科院分区：
文献类型：
--
作者：
Rice, Benjamin L.;Acosta, Monica M.;Pacheco, M. Andreina;Carlton, Jane M.;Barnwell, John W.;Escalante, Ananias A.
关键词：
疟原虫属是一组多样化的寄生虫，已知有200多个物种，包括那些引起人类疟疾的物种。这些寄生虫在一个复杂的过程中使用许多蛋白质，使它们能够侵入脊椎动物宿主的红细胞。这些蛋白质中的许多是多基因家族的一部分;其中之一是裂殖子表面蛋白3（msp 3）家族。msp 3多基因家族在两种主要的人类寄生虫间日疟原虫和恶性疟原虫中被认为是重要的，因为其旁系同源物在血液阶段（裂殖子）中同时表达并且是免疫原性的。疟原虫属物种之间在该科的旁系同源物数量上存在很大差异。这种差异以前曾被部分解释为允许不同疟原虫物种入侵其宿主的适应性。为了研究这一点，我们在几种疟原虫物种中表征了含有msp 3基因的阵列，包括恶性疟原虫和间日疟原虫。我们首先发现没有证据表明恶性疟原虫的msp 3家族与间日疟原虫的msp 3家族同源。随后，通过关注与间日疟原虫密切相关的非人灵长类寄生虫的不同分支，我们发现没有证据表明旁系同源物数量的种间变化是与宿主范围或宿主转换变化相关的适应。总体而言，我们假设间日疟原虫中msp 3家族的进化与多等位基因多样化选择的模型一致，其中旁系同源物在增加抗原多样性方面可能具有功能冗余的作用。因此，我们认为，表达的MSP 3蛋白可以作为“诱饵”，通过抗原多样性，在入侵宿主红细胞的关键过程中。
The genus Plasmodium is a diversified group of parasites with more than 200 known species that includes those causing malaria in humans. These parasites use numerous proteins in a complex process that allows them to invade the red blood cells of their vertebrate hosts. Many of those proteins are part of multi-gene families; one of which is the merozoite surface protein-3 (msp3) family. The msp3 multi-gene family is considered important in the two main human parasites, Plasmodium vivax and Plasmodium falciparum, as its paralogs are simultaneously expressed in the blood stage (merozoite) and are immunogenic. There are large differences among Plasmodium species in the number of paralogs in this family. Such differences have been previously explained, in part, as adaptations that allow the different Plasmodium species to invade their hosts. To investigate this, we characterized the array containing msp3 genes among several Plasmodium species, including P. falciparum and P. vivax. We first found no evidence indicating that the msp3 family of P. falciparum was homologous to that of P. vivax. Subsequently, by focusing on the diverse clade of nonhuman primate parasites to which P. vivax is closely related, where homology was evident, we found no evidence indicating that the interspecies variation in the number of paralogs was an adaptation related to changes in host range or host switches. Overall, we hypothesize that the evolution of the msp3 family in P. vivax is consistent with a model of multi-allelic diversifying selection where the paralogs may have functionally redundant roles in terms of increasing antigenic diversity. Thus, we suggest that the expressed MSP3 proteins could serve as “decoys”, via antigenic diversity, during the critical process of invading the host red blood cells.
登录
查看更多内容
疟原虫的抗原性和免疫原性蛋白质表面蛋白-3。
影响因子：
3.7
作者：
Bitencourt AR;Vicentin EC;Jimenez MC;Ricci R;Leite JA;Costa FT;Ferreira LC;Russell B;Nosten F;Rénia L;Galinski MR;Barnwell JW;Rodrigues MM;Soares IS
通讯作者：
Soares IS
影响因子：
64.8
作者：
Carlton, Jane M.;Adams, John H.;Silva, Joana C.;Bidwell, Shelby L.;Lorenzi, Hernan;Caler, Elisabet;Crabtree, Jonathan;Angiuoli, Samuel V.;Merino, Emilio F.;Amedeo, Paolo;Cheng, Qin;Coulson, Richard M. R.;Crabb, Brendan S.;del Portillo, Hernando A.;Essien, Kobby;Feldblyum, Tamara V.;Fernandez-Becerra, Carmen;Gilson, Paul R.;Gueye, Amy H.;Guo, Xiang;Kang'a, Simon;Kooij, Taco W. A.;Korsinczky, Michael;Meyer, Esmeralda V. -S.;Nene, Vish;Paulsen, Ian;White, Owen;Ralph, Stuart A.;Ren, Qinghu;Sargeant, Tobias J.;Salzberg, Steven L.;Stoeckert, Christian J.;Sullivan, Steven A.;Yamamoto, Marcio M.;Hoffman, Stephen L.;Wortman, Jennifer R.;Gardner, Malcolm J.;Galinski, Mary R.;Barnwell, John W.;Fraser-Liggett, Claire M.
通讯作者：
Fraser-Liggett, Claire M.
影响因子：
3.7
作者：
Jiang, Jianlin;Barnwell, John W.;Galinski, Mary R.
通讯作者：
Galinski, Mary R.
影响因子：
1.5
作者：
Galinski, MR;Ingravallo, P;Barnwell, JW
通讯作者：
Barnwell, JW
影响因子：
4.4
作者：
Liew KJ;Hu G;Bozdech Z;Peter PR
通讯作者：
Peter PR