Fast repetitive stretch suppresses denervation‐induced muscle fibrosis
Fast repetitive stretch suppresses denervation‐induced muscle fibrosis
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快速重复拉伸抑制去神经引起的肌肉纤维化
DOI：
10.1002/mus.27059
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发表时间：
2020
期刊：
影响因子：
3.4
通讯作者：
Yamazaki Toshiaki
中科院分区：
文献类型：
--
作者：
Tanaka Shoji;Inaoka Pleiades Tiharu;Yano Asami;Nakagawa Takao;Yamazaki Toshiaki
BackgroundWe aimed to examine the influence of different speeds of stretching on denervation-induced skeletal muscle fibrosis.MethodsStretching was passively applied to rat plantaris muscle denervated by sciatic nerve ectomy，in three different cycles of 0.5，3，or 12 cycles/min，for 20 min/d for 2 weeks.ResultsGene analysis results showed greater expression of fibrosis-related factors with fast stretching compared with non-stretching muscle.激光多普勒血流分析表明，在拉伸过程中肌内血流减少。组织学分析表明，纤维化面积减少12个周期/分钟拉伸肌肉相比，non‐ stretchedmuscle.ConclusionsSlower拉伸诱导更大的mRNA表达的胶原蛋白和成纤维细胞和更大的递减的血流量。组织学上，更快的拉伸抑制纤维化。这些结果表明，快速重复拉伸失神经肌肉可能会抑制肌肉纤维化的过程。
BackgroundWe aimed to examine the influence of different speeds of stretching on denervation‐induced skeletal muscle fibrosis.MethodsStretching was passively applied to rat plantaris muscle denervated by sciatic nerve excision in three different cycles of 0.5, 3, or 12 cycles/min, for 20 min/d for 2 weeks.ResultsGene analysis results showed greater expression of fibrosis‐related factors with fast stretching compared with non‐stretched muscle. Laser Doppler blood flow analysis indicated reduced intramuscular blood flow during stretching. Histological analysis demonstrated fibrotic area decreases in 12 cycles/min stretched muscle compared with non‐stretched muscle.ConclusionsSlower stretching induced greater mRNA expression of collagen and fibroblasts and greater decrement of blood flow. Histologically, faster stretching suppressed fibrosis. These results suggest that fast repetitive stretching of denervated muscle might suppress processes of muscle fibrosis.
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