Circulating serum xenoestrogens and mammographic breast density.
Circulating serum xenoestrogens and mammographic breast density.
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DOI：
10.1186/bcr3432
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发表时间：
2013-05-27
期刊：
影响因子：
--
通讯作者：
Burnside ES
中科院分区：
文献类型：
--
作者：
Sprague BL;Trentham-Dietz A;Hedman CJ;Wang J;Hemming JD;Hampton JM;Buist DS;Aiello Bowles EJ;Sisney GS;Burnside ES
人类广泛暴露于具有雌激素活性的邻苯二甲酸酯、对羟基苯甲酸酯和苯酚，引起了对乳腺组织和乳腺癌风险潜在影响的担忧。我们试图确定这些化学物质的循环血清水平（反映最近的暴露）与乳房X线摄影乳腺密度（乳腺癌风险的标志物）的关系。我们从威斯康星州麦迪逊的乳腺X线摄影诊所招募了年龄在55 - 70岁的绝经后妇女（N = 264）。受试者完成问卷调查并提供血液样本，分析其邻苯二甲酸单乙酯、邻苯二甲酸单丁酯、邻苯二甲酸单苄酯、对羟基苯甲酸丁酯、对羟基苯甲酸丙酯、辛基苯酚、壬基苯酚和双酚A（BPA）。通过使用计算机辅助阈值法从乳房X线照片测量乳腺密度百分比。校正年龄、体重指数和其他潜在混杂因素后，血清BPA与乳腺摄影乳腺密度呈正相关。平均百分比密度为12.6%（95%置信区间（CI）为11.4 - 14.0），在193名BPA水平检测不到的女性中，（95% CI，10.7至17.1）在35名女性中，检测水平低于中位数（<0.55 ng/ml），而在34名可检测水平高于中位数（>0.55 ng/ml; Ptrend = 0.01）的妇女中为17.6%（95%CI，14.1 - 21.5）。血清邻苯二甲酸单乙酯水平高于中位检测水平（>3.77 ng/ml）的18名女性的乳腺密度百分比也高于BPA水平未检测到的女性（13.1%; 95% CI，11.9至14.3; Ptrend = 0.07）。没有其他化学物质与乳腺密度百分比相关。血清BPA和邻苯二甲酸单乙酯水平高的绝经后妇女乳腺密度升高。需要通过重复血清测量或其他外源性雌激素暴露标志物进一步研究BPA和邻苯二甲酸单乙酯对乳腺癌风险的影响。
Humans are widely exposed to estrogenically active phthalates, parabens, and phenols, raising concerns about potential effects on breast tissue and breast cancer risk. We sought to determine the association of circulating serum levels of these chemicals (reflecting recent exposure) with mammographic breast density (a marker of breast cancer risk). We recruited postmenopausal women aged 55 to 70 years from mammography clinics in Madison, Wisconsin (N = 264). Subjects completed a questionnaire and provided a blood sample that was analyzed for mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, butyl paraben, propyl paraben, octylphenol, nonylphenol, and bisphenol A (BPA). Percentage breast density was measured from mammograms by using a computer-assisted thresholding method. Serum BPA was positively associated with mammographic breast density after adjusting for age, body mass index, and other potentially confounding factors. Mean percentage density was 12.6% (95% confidence interval (CI), 11.4 to 14.0) among the 193 women with nondetectable BPA levels, 13.7% (95% CI, 10.7 to 17.1) among the 35 women with detectable levels below the median (<0.55 ng/ml), and 17.6% (95% CI, 14.1 to 21.5) among the 34 women with detectable levels above the median (>0.55 ng/ml; Ptrend = 0.01). Percentage breast density was also elevated (18.2%; 95% CI, 13.4 to 23.7) among the 18 women with serum mono-ethyl phthalate above the median detected level (>3.77 ng/ml) compared with women with nondetectable BPA levels (13.1%; 95% CI, 11.9 to 14.3; Ptrend = 0.07). No other chemicals demonstrated associations with percentage breast density. Postmenopausal women with high serum levels of BPA and mono-ethyl phthalate had elevated breast density. Further investigation of the impact of BPA and mono-ethyl phthalate on breast cancer risk by using repeated serum measurements or other markers of xenoestrogen exposure are needed.
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影响因子：
3.3
作者：
Fernandez, M. F.;Arrebola, J. P.;Olea, N.
通讯作者：
Olea, N.
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ
影响因子：
--
作者：
Koch, HM;Preuss, R;Angerer, J
通讯作者：
Angerer, J
影响因子：
4.5
作者：
Baird DD;Saldana TM;Nepomnaschy PA;Hoppin JA;Longnecker MP;Weinberg CR;Wilcox AJ
通讯作者：
Wilcox AJ
影响因子：
3.3
作者：
Borch, J;Ladefoged, O;Vinggaard, AM
通讯作者：
Vinggaard, AM