Impact of Family History on the Risk of Breast Cancer among the Japanese
Impact of Family History on the Risk of Breast Cancer among the Japanese
复制标题
家族史对日本人乳腺癌风险的影响
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
S. Tokudome
中科院分区：
文献类型：
--
作者：
K. Hirose;K. Tajima;N. Hamajima;T. Kuroishi;S. Miura;S. Tokudome
为了评估家族史对患乳腺癌风险的影响，一项病例参考研究使用了日本爱知癌症中心（HERPACC）医院流行病学研究项目的数据。总共纳入了1551例乳腺癌病例，并招募了28450名确诊无癌症的妇女作为参照组。比值比（ORs）及其95%置信区间（95% ci）采用无条件logistic回归模型估计。按诊断年龄分层，评估家族史对早发病（<40岁）和晚发病（> 40岁）的影响。从本研究中获得的新发现如下。1)对于家庭成员患有卵巢癌的女性，40岁以下诊断为乳腺癌的OR为5.04 （95%CI: 1.48-17.1）。2)家族史对乳腺癌发病风险的影响，姐妹（姐妹）为阳性时（OR=3.51）大于母亲（OR=1.47）。3)除先证者外姐妹中乳腺癌的估计比例比（PR）为2.63 (95%CI: 2.05 3.38)，非乳腺癌的估计比例比（PR）为1.09 （95%CI: 0.94-1.27）。这一结果表明，有乳腺癌家族史的人，尤其是姐妹，患乳腺癌的风险会增加。此外，如果女性的姐妹在40岁之前被诊断患有乳腺癌，她们的乳腺癌家族史会影响她们患乳腺癌和其他器官癌症的风险。
To assess the impact of family history on the risk of developing breast cancer, a case‐referent study was conducted using data from the Hospital‐based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. In total, 1,551 breast cancer cases were included and 28,450 women, confirmed as free of cancer, were recruited as the reference group. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) were estimated by using an unconditional logistic regression model. Stratification by age at diagnosis was done to evaluate the impact of family history on early (<40 years of age) vs. later (≫40 years of age) onset. New findings obtained from the present study were as follows. 1) For women having a family member with ovarian cancer, the OR for breast cancer diagnosed under age 40 was 5.04 (95%CI: 1.48–17.1). 2) The effect of family history on the risk of breast cancer was greater when a sister(s) was (were) positive (OR=3.51) than when the mother was positive (OR=1.47). 3) The estimated proportional ratio (PR) for breast cancer was 2.63 (95%CI: 2.05 3.38) among sisters excluding probands, while PR for cancers other than breast cancer was 1.09 (95%CI: 0.94–1.27). This result suggested that a family history of breast cancer, especially among sisters, elevated the risk of developing breast cancer. Furthermore, when women had a sister(s) with breast cancer diagnosed prior to 40 years of age, their family history of breast cancer affected their risk of cancer of the breast and other organs.
妇科癌症家族史：与 55 岁之前乳腺癌发病率的关系。
影响因子：
7.7
作者：
Thompson,WD;Schildkraut,JM
通讯作者：
Schildkraut,JM
影响因子：
5
作者：
CLAUS, EB;RISCH, NJ;THOMPSON, D
通讯作者：
THOMPSON, D
影响因子：
56.9
作者：
MIKI, Y;SWENSEN, J;SKOLNICK, MH
通讯作者：
SKOLNICK, MH