Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry.
Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry.
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电针通过调节 rACC-丘脑回路缓解慢性疼痛引起的焦虑症
DOI：
10.3389/fnins.2020.615395
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发表时间：
2020
影响因子：
4.3
通讯作者：
Shao X
中科院分区：
文献类型：
--
作者：
Shen Z;Zhang H;Wu Z;He Q;Liu J;Xu Y;Yao S;He X;Chen Y;Liang Y;Liu B;Jiang Y;Fang J;Du J;Zhu X;Wu M;Wu Y;Sun J;Xu C;Fang J;Shao X
焦虑是慢性疼痛的常见合并症，导致慢性疼痛复杂化和治疗困难。电针（EA）通常用于治疗慢性疼痛和焦虑。然而，EA效应的潜在机制在很大程度上是未知的。在这里，我们表明，慢性疼痛的潜在电路引起焦虑症，EA可以通过调节这种电路来治疗它们。使用化学发生学的方法，我们发现，化学发生学激活的喙前扣带皮层（rACC）的丘脑神经元能输出诱导焦虑症在对照组大鼠。然后，rACC-丘脑回路的化学发生抑制减少了足底注射完全弗氏佐剂（CFA）产生的焦虑样行为。本研究旨在探讨电针对CFA介导的焦虑样行为大鼠模型的影响及其相关机制。我们发现，rACC-丘脑回路的化学发生激活有效地阻断了EA对CFA大鼠慢性疼痛诱导的焦虑样行为的影响。这些结果表明，一个潜在的rACC-丘脑神经元通路，调节CFA介导的焦虑样行为。本研究还为电针治疗慢性疼痛引起的焦虑提供了一个潜在的机制解释。
Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain complexification and difficulty in treatment. Electroacupuncture (EA) is commonly used to treat chronic pain and anxiety. However, the underlying mechanisms of the EA effect are largely unknown. Here, we showed that a circuitry underlying chronic pain induces anxiety disorders, and EA can treat them by regulating such circuitry. Using chemogenetic methods, we found that chemogenetic activation of the rostral anterior cingulate cortex (rACC) glutamatergic output to the thalamus induced anxiety disorders in control rats. Then, chemogenetic inhibition of the rACC-thalamus circuitry reduced anxiety-like behavior produced by intraplantar injection of the complete Freund’s adjuvant (CFA). In this study, we examined the effects of EA on a rat model of CFA-mediated anxiety-like behaviors and the related mechanisms. We found that chemogenetic activation of the rACC-thalamus circuitry effectively blocked the effects of EA on chronic pain-induced anxiety-like behaviors in CFA rats. These results demonstrate an underlying rACC-thalamus glutamatergic circuitry that regulates CFA-mediated anxiety-like behaviors. This study also provides a potential mechanistic explanation for EA treatment of anxiety caused by chronic pain.
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影响因子：
4.7
作者：
McLaughlin I;Dani JA;De Biasi M
通讯作者：
De Biasi M
影响因子：
7.4
作者：
Gerrits, Marloes M. J. G.;van Oppen, Patricia;van der Horst, Henritte E.
通讯作者：
van der Horst, Henritte E.
慢性应激通过激活大鼠的 rACC-BLA 通路增加疼痛敏感性
影响因子：
5.3
作者：
Liu，Ling-Yu;Zhang，Rui-Ling;Xing，Guo-Gang
通讯作者：
Xing，Guo-Gang
影响因子：
10.6
作者：
Huys, Daniel;Bartsch, Christina;Kuhn, Jens
通讯作者：
Kuhn, Jens
影响因子：
3.4
作者：
Li, Yonghui;Li, Sa;Kirouac, Gilbert J.
通讯作者：
Kirouac, Gilbert J.