The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation.
The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation.
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DOI：
10.1111/jnc.14008
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发表时间：
2017-08
影响因子：
4.7
通讯作者：
De Biasi M
中科院分区：
文献类型：
--
作者：
McLaughlin I;Dani JA;De Biasi M
戒除长期使用成瘾药物会引发一种令人厌恶的戒断综合征，这种综合征会迫使成瘾药物复发并阻止戒除。这种综合征的许多特征在多种药物中是共同的，涉及情感和身体症状。戒断症状背后的一些网络信号与厌恶情绪状态（包括焦虑和抑郁）相关的活动重叠。鉴于这些共同的特征，这并不奇怪，一个特定的电路，背间脑传导系统，特别是内侧缰核和脚间核（MHb-IPN），已被确定为出现厌恶状态的关键，这既是药物成瘾的结果，也是独立的。随着该回路的特征继续被表征，MHb-IPN轴正在成为治疗剂的可行靶点，以帮助治疗多种滥用药物成瘾以及情绪相关疾病。
Abstinence from chronic use of addictive drugs triggers an aversive withdrawal syndrome that compels relapse and deters abstinence. Many features of this syndrome are common across multiple drugs, involving both affective and physical symptoms. Some of the network signaling underlying withdrawal symptoms overlaps with activity that is associated with aversive mood states, including anxiety and depression. Given these shared features, it is not surprising that a particular circuit, the dorsal diencephalic conduction system, and the medial habenula and interpeduncular nucleus (MHb-IPN) in particular, have been identified as critical to the emergence of aversive states that arise both as a result, and independently, of drug addiction. As the features of this circuit continue to be characterized, the MHb-IPN axis is emerging as a viable target for therapeutics to aid in the treatment of addiction to multiple drugs of abuse as well as mood-associated disorders.
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影响因子：
3.7
作者：
Bajic D;Soiza-Reilly M;Spalding AL;Berde CB;Commons KG
通讯作者：
Commons KG
外侧Habenula在惩罚中的作用。
影响因子：
3.7
作者：
Jean-Richard Dit Bressel P;McNally GP
通讯作者：
McNally GP
缰核：脊椎动物大脑中保守的不对称中继站。
DOI：
10.1098/rstb.2008.0213
发表时间：
2009-04-12
影响因子：
6.3
作者：
Bianco, Isaac H.;Wilson, Stephen W.
通讯作者：
Wilson, Stephen W.
影响因子：
5.3
作者：
Dao, Dang Q.;Perez, Erika E.;De Biasi, Mariella
通讯作者：
De Biasi, Mariella
影响因子：
4.7
作者：
Cougle, Jesse R.;Zvolensky, Michael J.;Sachs-Ericsson, Natalie
通讯作者：
Sachs-Ericsson, Natalie