Musical instrument training program improves verbal memory and neural efficiency in novice older adults.
Musical instrument training program improves verbal memory and neural efficiency in novice older adults.
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DOI：
10.1002/hbm.25298
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发表时间：
2021-04-01
影响因子：
4.8
通讯作者：
Sekiyama K
中科院分区：
文献类型：
--
作者：
Guo X;Yamashita M;Suzuki M;Ohsawa C;Asano K;Abe N;Soshi T;Sekiyama K
先前的研究表明，乐器训练可以改善老年人的认知功能。然而，人们对与训练相关的认知功能改善的神经起源知之甚少。在这里，我们评估了器乐训练计划对不懂音乐的老年人（61-85 岁）认知功能和神经效率的影响。参与者被分配到干预组和对照组，其中干预组接受为期 4 个月的键盘口琴乐器培训计划，对照组则没有任何替代培训。在两组干预前后进行视觉工作记忆（VWM）任务期间的认知测量和功能磁共振成像。行为数据显示，与对照组相比，干预组在测量言语回忆的测试中显着提高了记忆表现。神经影像数据显示，仅在干预组中，在 VWM 任务期间，右侧辅助运动区、左侧楔前叶和双侧后扣带回 (PCgG) 的大脑激活在仪器训练后有所下降。任务相关功能连接（FC）分析显示，干预组在干预后的 VWM 任务中，右侧 PCgG 和左侧颞中回之间以及左侧壳核和右侧颞上回 (lPu-rSTG) 之间的 FC 降低。此外，干预组记忆表现的更大改善与 lPu-rSTG FC 的更大减少相关，这可能被解释为神经效率的提高。我们的结果表明，乐器训练计划可能有助于提高新手老年人的语言记忆和神经效率。该研究表明，在器乐训练计划之后，老年人的神经效率有所提高（与任务相关的大脑激活和功能连接减少）。此外，这还伴随着非音乐言语记忆的行为表现的改善。目前的研究结果为老年人乐器训练相关的可塑性提供了新的因果证据。
Previous studies indicate that musical instrument training may improve the cognitive function of older adults. However, little is known about the neural origins of training‐related improvement in cognitive function. Here, we assessed the effects of instrumental training program on cognitive functions and neural efficiency in musically naïve older adults (61–85 years old). Participants were assigned to either the intervention group, which received a 4‐month instrumental training program using keyboard harmonica, or a control group without any alternative training. Cognitive measurements and functional magnetic resonance imaging during visual working memory (VWM) task were administered before and after the intervention in both groups. Behavioral data revealed that the intervention group significantly improved memory performance on the test that measures verbal recall compared to the control group. Neuroimaging data revealed that brain activation in the right supplementary motor area, left precuneus, and bilateral posterior cingulate gyrus (PCgG) during the VWM task decreased after instrumental training only in the intervention group. Task‐related functional connectivity (FC) analysis revealed that the intervention group showed decreased FC between the right PCgG and left middle temporal gyrus, and between the left putamen and right superior temporal gyrus (lPu‐rSTG) during a VWM task after the intervention. Furthermore, a greater improvement in memory performance in the intervention group was associated with a larger reduction in lPu‐rSTG FC, which might be interpreted as improved neural efficiency. Our results indicate that the musical instrument training program may contribute to improvements in verbal memory and neural efficiency in novice older adults. The study demonstrated increased neural efficiency (decreased task‐related brain activation and functional connectivity) in older adults after the instrumental training program. Moreover, this was accompanied by improved behavioral performances in non‐musical verbal memory. The present findings provide new causal evidence for instrumental training‐related plasticity in older adults.
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影响因子：
3.7
作者：
Basak, Chandramallika;Boot, Walter R.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
3.6
作者：
Elmer, Stefan;Haenggi, Juergen;Jaencke, Lutz
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Jaencke, Lutz
影响因子：
9.9
作者：
Hall, C. B.;Lipton, R. B.;Verghese, J.
通讯作者：
Verghese, J.
乐器音乐活动与认知老化之间的关系。
影响因子：
2.4
作者：
Hanna-Pladdy, Brenda;MacKay, Alicia
通讯作者：
MacKay, Alicia
影响因子：
3.4
作者：
Bugos, J. A.;Perlstein, W. M.;Bedenbaugh, P. H.
通讯作者：
Bedenbaugh, P. H.