Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease.
Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease.
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DOI：
10.1002/jmri.24321
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发表时间：
2014-06
影响因子：
4.4
通讯作者：
Sirlin, Claude B.
中科院分区：
文献类型：
--
作者：
Bonekamp, Susanne;Tang, An;Mashhood, Arian;Wolfson, Tanya;Changchien, Christopher;Middleton, Michael S.;Clark, Lisa;Gamst, Anthony;Loomba, Rohit;Sirlin, Claude B.
关键词：
利用磁共振成像（MRI）估算的质子密度脂肪分数（PDFF）描述非酒精性脂肪性肝病（NAFLD）成人患者肝脏脂肪的空间分布。
这项经机构审查委员会批准且符合《健康保险流通与责任法案》的研究前瞻性纳入了50名经活检证实患有NAFLD的成人（30名女性，20名男性）。在3T磁场下，通过低翻转角多回波破坏梯度回波MRI测量肝脏PDFF。在每个肝段内放置三个不重叠的感兴趣区域。统计分析包括皮尔逊相关性分析、多变量线性回归以及基于排列的配对检验。
研究人群的平均全肝PDFF为16.1%（范围：1.6% - 39.6%）。平均全肝PDFF变异度为1.9%（范围：0.7% - 4.5%）。较高的变异度与较高的PDFF相关（r = 0.34，p = 0.0156）。右叶的平均PDFF显著高于左叶（16.5%对15.3%，p = 0.0028）。左叶的平均PDFF变异度高于右叶（1.86%对1.28%，p < 0.0001）。Ⅱ段的平均节段性PDFF最低（14.8%）；Ⅷ段最高（16.7%）。Ⅴ段（0.71%）和Ⅵ段（0.70%）的平均节段性PDFF变异度最低；Ⅱ段最高（1.32%）。
在成人NAFLD中，肝叶之间以及一些肝段之间在脂肪含量和变异度上存在微小但显著的差异。
To describe the spatial distribution of liver fat, using magnetic resonance imaging (MRI)-estimated proton density fat fraction (PDFF), in adults with non-alcoholic fatty liver disease (NAFLD). This IRB-approved, HIPAA-compliant study prospectively enrolled fifty adults (30 women, 20 men) with biopsy-proven NAFLD. Hepatic PDFF was measured by low-flip-angle multiecho spoiled gradient-recalled-echo MRI at 3T. Three non-overlapping regions of interest were placed within each liver segment. Statistical analyses included Pearson’s correlation, multivariable linear regression, and permutation-based paired tests. The study population’s mean whole-liver PDFF was 16.1% (range: 1.6–39.6%). The mean whole-liver PDFF variability was 1.9% (range: 0.7–4.5%). Higher variability was associated with higher PDFF (r=0.34, p=0.0156). The mean PDFF was significantly higher in the right lobe than the left (16.5% vs. 15.3%, p=0.0028). The mean PDFF variability was higher in the left lobe than the right (1.86% vs. 1.28%, p<0.0001). Segment II had the lowest mean segmental PDFF (14.8%); segment VIII had the highest (16.7%). Segments V (0.71%) and VI (0.70%) had the lowest mean segmental PDFF variability; segment II had the highest (1.32%). In adult NAFLD there are small but significant differences in fat content and variability between lobes and some of the segments.
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影响因子：
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通讯作者：
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通讯作者：
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