T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis.
T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis.
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DOI：
10.1002/jmri.22514
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发表时间：
2011-04
影响因子：
4.4
通讯作者：
Reeder, Scott B.
中科院分区：
文献类型：
--
作者：
Hines, Catherine D. G.;Frydrychowicz, Alex;Hamilton, Gavin;Tudorascu, Dana L.;Vigen, Karl K.;Yu, Huanzhou;McKenzie, Charles A.;Sirlin, Claude B.;Brittain, Jean H.;Reeder, Scott B.
以单体素磁共振波谱（MRS）作为参考标准，确定基于化学位移的磁共振成像（MRI）脂肪 - 水分离方法所测量的肝脏脂肪分数的精密度和准确度。
在42例患者中，使用基于与T1无关且经\(T_2^*\)校正的化学位移的脂肪 - 水分离方法（对脂肪进行多峰谱建模）以及经T2校正的单体素磁共振波谱进行了两次重复测量。通过计算布兰德 - 奥特曼图和一致性相关区间来评估精密度。通过MRI和MRS之间的线性回归来评估准确度。还计算了以MRS作为参考标准时，MRI脂肪分数对脂肪变性诊断的敏感度和特异度。
统计分析表明，MRI和MRS脂肪分数具有极佳的精密度，单个MRI感兴趣区域（ROI）测量的95%置信区间（绝对百分比单位）为[−2.66%, 2.64%]，平均MRI ROI为[−0.81%, 0.80%]，单体素MRS为[−2.70%, 2.87%]，这表明了精密度情况。MRI和MRS之间的线性回归表明MRI方法具有高度的准确性。使用平均MRI ROI检测脂肪变性的敏感度和特异度分别为100%和94%。还研究了肝脏脂肪分数与体重指数之间的关系。
使用与T1无关且经\(T_2^*\)校正的MRI以及脂肪多峰谱建模所测量的脂肪分数是一种对肝脏脂肪变性进行量化的高精度和高准确度的方法。
To determine the precision and accuracy of hepatic fat-fraction measured with a chemical shift-based MRI fat-water separation method, using single-voxel MR spectroscopy (MRS) as a reference standard. In 42 patients, two repeated measurements were made using a T1-independent, -corrected chemical shift-based fat-water separation method with multi-peak spectral modeling of fat, and T2-corrected single voxel MR spectroscopy. Precision was assessed through calculation of Bland-Altman plots and concordance correlation intervals. Accuracy was assessed through linear regression between MRI and MRS. Sensitivity and specificity of MRI fat-fractions for diagnosis of steatosis using MRS as a reference standard were also calculated. Statistical analysis demonstrated excellent precision of MRI and MRS fat-fractions, indicated by 95% confidence intervals (units of absolute percent) of [−2.66%,2.64%] for single MRI ROI measurements, [−0.81%,0.80%] for averaged MRI ROI, and [−2.70%,2.87%] for single-voxel MRS. Linear regression between MRI and MRS indicated that the MRI method is highly accurate. Sensitivity and specificity for detection of steatosis using averaged MRI ROI were 100% and 94%, respectively. The relationship between hepatic fat-fraction and body mass index was examined. Fat-fraction measured with T1-independent -corrected MRI and multi-peak spectral modeling of fat is a highly precise and accurate method of quantifying hepatic steatosis.
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影响因子：
5.1
作者：
McCullough, Arthur J
通讯作者：
McCullough, Arthur J
影响因子：
3.3
作者：
Brau, Anja C. S.;Beatty, Philip J.;Bammer, Roland
通讯作者：
Bammer, Roland
影响因子：
19.7
作者：
Hines, Catherine D. G.;Yu, Huanzhou;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
7.7
作者：
Marchesini, G;Brizi, M;Melchionda, N
通讯作者：
Melchionda, N
影响因子：
5.1
作者：
Harrison, Stephen A;Neuschwander-Tetri, Brent A
通讯作者：
Neuschwander-Tetri, Brent A