Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure-volume curves.
Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure-volume curves.
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DOI：
10.1038/s41598-022-16650-0
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发表时间：
2022-07-19
影响因子：
4.6
通讯作者：
Suki, Bela
中科院分区：
文献类型：
--
作者：
Shi, Linzheng;Herrmann, Jacob;Jawde, Samer Bou;Bates, Jason H. T.;Nia, Hadi T.;Suki, Bela
人肺压力 (P) 和容积 (V) 之间的关系已得到广泛研究。然而，重力以及弹性蛋白和胶原蛋白的机械特性对呼吸过程中肺泡和肺 P-V 曲线的综合影响尚不清楚。在这里，我们扩展了先前建立的在正压充气期间具有波状胶原纤维的单个肺泡的厚壁球形模型。首先，我们更新了负压驱动的充气模型，该模型允许结合重力引起的胸膜压力梯度来预测整个直立人肺中静态肺泡 P-V 关系如何在空间上变化。其次，通过引入动态表面张力和胶原粘弹性，我们计算了肺 P-V 曲线的滞后回线。通过将预测的区域通风与文献数据进行比较来测试该模型，从而深入了解微重力对通风的影响。该模型还为未来关于间隔壁机械应力变化以及胶原蛋白和弹性蛋白纤维对 P-V 曲线和整个肺部的贡献的实验提供了新颖的可测试预测。该模型可以帮助我们更好地理解呼吸和胸膜压力变化产生的机械应力如何影响肺部的区域细胞机械转导。
The relationship between pressure (P) and volume (V) in the human lung has been extensively studied. However, the combined effects of gravity and the mechanical properties of elastin and collagen on alveolar and lung P–V curves during breathing are not well understood. Here, we extended a previously established thick-walled spherical model of a single alveolus with wavy collagen fibers during positive pressure inflation. First, we updated the model for negative pressure-driven inflation that allowed incorporation of a gravity-induced pleural pressure gradient to predict how the static alveolar P–V relations vary spatially throughout an upright human lung. Second, by introducing dynamic surface tension and collagen viscoelasticity, we computed the hysteresis loop of the lung P–V curve. The model was tested by comparing its predicted regional ventilation to literature data, which offered insight into the effects of microgravity on ventilation. The model has also produced novel testable predictions for future experiments about the variation of mechanical stresses in the septal walls and the contribution of collagen and elastin fibers to the P–V curve and throughout the lung. The model may help us better understand how mechanical stresses arising from breathing and pleural pressure variations affect regional cellular mechanotransduction in the lung.
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肺肺泡的微力学：表面活性剂和组织成分的结构和功能。
影响因子：
2.3
作者：
Knudsen L;Ochs M
通讯作者：
Ochs M
影响因子：
3.3
作者：
Altemeier, WA;McKinney, S;Glenny, RW
通讯作者：
Glenny, RW
影响因子：
2.5
作者：
Casha, Aaron R.;Caruana-Gauci, Roberto;Scarci, Marco
通讯作者：
Scarci, Marco
影响因子：
15.1
作者：
de Carvalho, Maria-Eudoxia Pilotto;Dolhnikoff, Marisa;Deheinzelin, Daniel
通讯作者：
Deheinzelin, Daniel
DOI：
10.1115/1.2794178
发表时间：
1995-08-01
影响因子：
1.7
作者：
DENNY, E;SCHROTER, RC
通讯作者：
SCHROTER, RC