Clinical factors associated with fatigue over time in paediatric oncology patients receiving chemotherapy.
Clinical factors associated with fatigue over time in paediatric oncology patients receiving chemotherapy.
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DOI：
10.1038/sj.bjc.6604434
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发表时间：
2008-07-08
影响因子：
8.8
通讯作者：
Chuang, H-L
中科院分区：
文献类型：
--
作者：
Yeh, C-H;Chiang, Y-C;Lin, L.;Yang, C-P;Chien, L-C;Weaver, M. A.;Chuang, H-L
本研究的目的是调查临床因素（包括血红蛋白值，化疗药物和皮质类固醇的使用）和疲劳模式的变化之前和之后的10天开始新一轮化疗的癌症儿童之间的关系。采用前瞻性纵向设计，收集了48例即将开始开始新一轮化疗的儿童肿瘤患者及其父母的数据。使用多领域问卷评估疲劳水平，其中包括三类患者自我报告（包括“一般焦虑”、“睡眠/休息焦虑”和“认知焦虑”）和四类父母代理报告（包括“缺乏能量”、“无法工作”、“睡眠改变”和“情绪改变”）。研究结果表明，疲劳从病人自我报告和父母代理报告显着改变随着时间的推移。这项研究的主要发现是，患者在化疗周期开始后的头几天有更多的疲劳问题。皮质类固醇的使用和血红蛋白值与持续数天的疲劳显着增加，并在第5天达到最高水平的疲劳，对于那些接受并发类固醇。化疗药物与疲劳的相关性在患者自我报告和家长报告之间有所不同，但所使用的化疗药物类型与疲劳的大多数变化无关。
The purpose of this study was to investigate the relationships between clinical factors (including haemoglobin value, chemotherapeutic agents, and corticosteroid use) and changing patterns of fatigue before and for the next 10 days following the start of a new round of chemotherapy in children with cancer. A prospective longitudinal design was used to collect data from 48 paediatric oncology patients who were about to begin a new round of chemotherapy and their parents. Fatigue levels were assessed using multidomain questionnaires with three categories of patient self-report (including ‘General Fatigue’, ‘Sleep/Rest Fatigue’, and ‘Cognitive Fatigue’) and four categories of parent proxy-report (including ‘Lack of Energy’, ‘Unable to Function’, ‘Altered Sleep’, and ‘Altered Mood’). The findings suggest that fatigue from both patient self-report and parent proxy-report changed significantly over time. The major findings from this study are that patients have more problems with fatigue in the first few days after the start of a cycle of chemotherapy. Corticosteroid use and haemoglobin value were associated with significant increases in fatigue that were sustained for several days and reached the highest level of fatigue at day 5 for those receiving concurrent steroids. The association of chemotherapeutic agents with fatigue varied between patient self-report and parent report, but the type of chemotherapeutic agents used was not associated with most changes in fatigue.
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影响因子：
2.6
作者：
Gibson, F;Garnett, M;Sepion, B
通讯作者：
Sepion, B
影响因子：
4.7
作者：
Collins, JJ;Devine, TD;Portenoy, RK
通讯作者：
Portenoy, RK
影响因子：
6.2
作者：
Varni, JW;Burwinkle, TM;Dickinson, P
通讯作者：
Dickinson, P
影响因子：
4.2
作者：
Chiang, Yi-Chien;Hinds, Pamela S.;Yang, Chao-Ping
通讯作者：
Yang, Chao-Ping
影响因子：
0.8
作者：
GALECKI, AT
通讯作者：
GALECKI, AT