Retrograde determination of motoneuron properties and their synaptic input.

Retrograde determination of motoneuron properties and their synaptic input.
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运动神经元特性及其突触输入的逆行测定。

DOI:
10.1002/neu.480250610
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发表时间:
1994
期刊:
Journal of neurobiology
影响因子:
--
通讯作者:
Munson,JB
Munson,JB
中科院分区:
--
文献类型:
--
作者:
Mendell,LM;Collins3rd,WF;Munson,JB

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运动神经元和它们所支配的肌纤维的特性差异很大。这些特性高度相关的发现表明这些细胞不是独立指定的,而是以某种方式相互作用以实现观察到的一致性。相互作用的方向,即顺行还是逆行,需要的分析超出了对这些相关特性的简单观察。主要来自涉及原始或外来运动神经对肌肉进行神经支配的实验的证据表明,来自肌肉的逆行转运因子以及顺行因子的作用。各种可能的因子,特别是神经营养因子,被认为是逆行规范的可能候选因子。此外,运动神经元的突触输入也以协调的方式变化,这表明肌肉的逆行决定。然而,运动神经元特性及其突触输入在外周神经操作后发生变化,以致它们不再处于记录状态。这表明运动神经元及其突触输入的逆行规范具有一定的独立性。 1994 约翰·威利父子公司
Both motoneurons and the muscle fibers that they innervate can vary widely in their properties. The finding that these properties are highly correlated indicates that these cells are not specified independently, but rather interact in some manner to achieve the observed coherence. The direction of the interaction, i.e., whether orthograde or retrograde, required analysis beyond the simple observation of these correlated properties. Evidence, largely from experiments involving reinnervation of muscle by the original or a foreign motor nerve, suggests the action of retrogradely transported factors from the muscle as well as orthograde ones. Various possible factors, specifically neurotrophins, are advanced as possible candidates for retrograde specification. In addition, synaptic input to motoneurons also varies in a coordianted fashion in a manner that suggests a retrograde determination from the muscle. However, motoneuron properties and their synaptic input change after peipheral nerve manipulations such that they are no longer in register. This indicates some independence in retrograde specification of motoneurons and their synaptic input. 1994 John Wiley & Sons, Inc.
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