Ecologies, synergies, and biological systems shaping human milk composition-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 2.
Ecologies, synergies, and biological systems shaping human milk composition-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 2.
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DOI：
10.1016/j.ajcnut.2022.11.027
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发表时间：
2023-04
期刊：
影响因子：
--
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中科院分区：
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母乳被普遍认为是婴儿在出生后6个月内的首选食物，因为它不仅提供必要量的必需和条件必需营养素，而且还提供其他生物活性成分，这些成分有助于保护婴儿、传递重要信息以支持婴儿和促进婴儿的最佳发育和生长。然而，尽管经过数十年的研究，母乳消费对婴儿健康的多方面影响远未在生物或生理基础上得到理解。对母乳功能缺乏全面了解的原因有很多，包括牛奶成分往往被孤立地研究，尽管有理由相信它们相互作用。此外，乳成分在个体内以及在群体内和群体间可能差异很大。母乳生态学：婴儿营养起源（开始）项目中的该工作组的目标是提供母乳成分的概述，影响其变化的因素，以及其成分如何协调营养，保护和传达复杂的信息给接受婴儿。此外，我们还讨论了牛奶成分可能相互作用的方式，使一个完整的牛奶基质的好处大于其部分的总和。然后，我们应用几个例子来说明如何更好地认为牛奶是一个生物系统，而不是一个更简单的“混合物”的独立组件，以协同支持最佳的婴儿健康。
Human milk is universally recognized as the preferred food for infants during the first 6 mo of life because it provides not only essential and conditionally essential nutrients in necessary amounts but also other biologically active components that are instrumental in protecting, communicating important information to support, and promoting optimal development and growth in infants. Despite decades of research, however, the multifaceted impacts of human milk consumption on infant health are far from understood on a biological or physiological basis. Reasons for this lack of comprehensive knowledge of human milk functions are numerous, including the fact that milk components tend to be studied in isolation, although there is reason to believe that they interact. In addition, milk composition can vary greatly within an individual as well as within and among populations. The objective of this working group within the Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN) Project was to provide an overview of human milk composition, factors impacting its variation, and how its components may function to coordinately nourish, protect, and communicate complex information to the recipient infant. Moreover, we discuss the ways whereby milk components might interact such that the benefits of an intact milk matrix are greater than the sum of its parts. We then apply several examples to illustrate how milk is better thought of as a biological system rather than a more simplistic “mixture” of independent components to synergistically support optimal infant health.
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DOI：
10.1590/1984-0462/;2018;36;2;00015
发表时间：
2018-04
期刊：
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
影响因子：
--
作者：
Codo CRB;Caldas JPS;Peixoto RRA;Sanches VL;Guiraldelo TC;Cadore S;Marba STM
通讯作者：
Marba STM
影响因子：
3.1
作者：
Contador, Rebeca;Delgado-Adamez, Jonathan;Ramirez, Rosario
通讯作者：
Ramirez, Rosario
影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
影响因子：
3.5
作者：
Argov-Argaman, Nurit
通讯作者：
Argov-Argaman, Nurit
影响因子：
2.6
作者：
Chomchai, Chulathida;Chomchai, Summon;Kitsommart, Ratchada
通讯作者：
Kitsommart, Ratchada