Food insecurity is associated with higher respiratory quotient and lower glucagon-like peptide 1.
Food insecurity is associated with higher respiratory quotient and lower glucagon-like peptide 1.
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DOI：
10.1002/oby.23437
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发表时间：
2022-06
期刊：
影响因子：
--
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众所周知，粮食不安全与肥胖有关，但其与生理指标的关系尚不清楚。因此，我们假设与食物安全相比，食物不安全的个体将具有更高的24小时能量消耗（EE[kcal/d]）和24小时呼吸商（RQ[比率]）。随后，我们探讨了参与食欲调节、底物氧化和EE的激素。113名非糖尿病健康受试者（75名男性;年龄40±12 [岁]; BMI 30±8 [kg/m2]）被纳入本分析。参与者完成了食品安全简表，DXA扫描，并在维持体重的饮食后在人类呼吸室中度过了24小时。与食物安全的个体相比，食物不安全的参与者在24小时EE中没有差异。但是，他们有更高的碳水化合物氧化率（p = 0.03）和更低的脂质氧化率（p = 0.02），导致更高的24小时RQ（p<0.01）。他们的空腹胰高血糖素样肽1（GLP-1 [p = 0.03]）浓度也较低。食物不安全与较高的24小时RQ和较低的空腹GLP-1浓度、代谢和激素差异相关，这些差异先前被证明在不受限制的食物供应情况下会导致更大的卡路里摄入。因此，我们的研究结果为限制食物获取和肥胖增加之间的矛盾联系提供了新的见解。
Food insecurity is known to be associated with obesity but its association with physiological measures is unclear. Therefore, we hypothesized that compared to food secure, individuals with food insecurity would have higher 24-h energy expenditure (EE[kcal/d]) and a 24-h respiratory quotient (RQ[ratio]). Subsequently, we explored hormones involved in appetite regulation, substrate oxidation, and EE. One hundred-thirteen non-diabetic healthy participants (75M; Age 40±12 [years]; BMI 30±8 [kg/m2]) were included in this analysis. Participants completed the Food Security Short Form, a DXA scan, and spent 24 hours in a human respiratory chamber following a weight maintaining diet. Compared to individuals with food security, participants with food insecurity had no difference in 24-h EE. However, they had higher carbohydrate oxidation rates (p = 0.03), and lower lipid oxidation rates (p = 0.02), resulting in higher 24-h RQ (p<0.01). They also had lower fasting glucagon-like peptide 1 (GLP-1 [p = 0.03]) concentrations. Food insecurity is associated with higher 24-h RQ and lower fasting GLP-1 concentrations, metabolic and hormonal differences previously shown to drive greater calorie intake in the setting of unrestricted food availability. Our findings therefore provide new insight into the paradoxical link between restricted food access and increased adiposity.
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在夜间食者中，较高的24小时呼吸商和较高的自发体育锻炼。
DOI：
10.1038/oby.2010.206
发表时间：
2011-03
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Gluck ME;Venti CA;Salbe AD;Votruba SB;Krakoff J
通讯作者：
Krakoff J
影响因子：
1.9
作者：
Banerjee, Srikanta;Radak, Tim;Dunn, Patrick
通讯作者：
Dunn, Patrick
影响因子：
2.7
作者：
Bateson M;Andrews C;Dunn J;Egger CBCM;Gray F;Mchugh M;Nettle D
通讯作者：
Nettle D
影响因子：
7.1
作者：
FERRARO, R;BOYCE, VL;RAVUSSIN, E
通讯作者：
RAVUSSIN, E
影响因子：
4.2
作者：
Leung, Cindy W.;Epel, Elissa S.;Laraia, Barbara A.
通讯作者：
Laraia, Barbara A.