Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells.
Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells.
复制标题
对天然和合成类视黄醇的凋亡活性的研究：发现一类新型合成三联苯，可有效支持神经元和 HL-60 细胞的细胞生长并抑制细胞凋亡。
DOI：
--
复制
发表时间：
2005
影响因子：
7.3
通讯作者：
M. Tolomeo
中科院分区：
文献类型：
--
作者：
D. Simoni;G. Giannini;M. Roberti;R. Rondanin;R. Baruchello;M. Rossi;G. Grisolia;F. Invidiata;S. Aiello;S. Marino;S. Cavallini;A. Siniscalchi;N. Gebbia;L. Crosta;S. Grimaudo;V. Abbadessa;A. Di Cristina;M. Tolomeo
合成了新的三联苯衍生物，并测试了它们在无血清培养中对细胞存活的影响。这些化合物保护HL60细胞免于死亡，并支持它们的生长，其活性高于天然14-羟基视黄醇。三苯基26和28对神经细胞也具有抗凋亡活性，证明它们可能是治疗神经退行性疾病和缺血性疾病的候选药物。
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
构象限制的类维生素A。
影响因子：
7.3
作者：
Dawson,MI;Hobbs,PD;Derdzinski,K;Chan,RL;Gruber,J;Chao,WR;Smith,S;Thies,RW;Schiff,LJ
通讯作者：
Schiff,LJ
影响因子：
7.3
作者：
JONG, L;LEHMANN, JM;DAWSON, MI
通讯作者：
DAWSON, MI
影响因子：
2.7
作者：
Dawson, MI;Jong, L;Zhang, XK
通讯作者：
Zhang, XK