Highlights from the 7th Cachexia Conference: muscle wasting pathophysiological detection and novel treatment strategies.
Highlights from the 7th Cachexia Conference: muscle wasting pathophysiological detection and novel treatment strategies.
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DOI：
10.1007/s13539-014-0136-z
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发表时间：
2014-03
影响因子：
8.9
通讯作者：
von Haehling, Stephan
中科院分区：
文献类型：
--
作者：
Ebner, Nicole;Steinbeck, Lisa;Doehner, Wolfram;Anker, Stefan D.;von Haehling, Stephan
本文重点介绍了2013年12月在日本科比举行的第7届恶病质会议上提出的消耗性疾病领域的临床前和临床研究。今年的主要议题是恶病质和消耗性疾病领域的新方法和新生物标志物的开发，特别关注炎症途径，生长分化因子-15，肌生成抑制素，泛素蛋白酶体依赖性途径，valosin和参与肌生成素和肌球蛋白重链分化的泛素特异性蛋白酶19的调节。这篇文章提出了亮点，从药物的发展，已显示出潜在的治疗消耗性疾病，特别是生长激素释放肽受体激动剂anamorelin，肌肉生长抑制素拮抗剂REGN1033，选择性雄激素受体调节剂enobosarm和TEI-E0001，和合成代谢分解代谢转化剂espindolol。此外，还提供了关于肌肉萎缩/肌肉减少症的患病率和检测方法的新数据，包括D3-肌酸稀释法和几种新的生物标志物。
This article highlights preclinical and clinical studies in the field of wasting disorders that were presented at the 7th Cachexia Conference held in Kobe, Japan, in December 2013. This year, the main topics were the development of new methods and new biomarkers in the field of cachexia and wasting disorders with particular focus on inflammatory pathways, growth differentiation factor-15, myostatin, the ubiquitin proteasome-dependent pathway, valosin and the regulation of ubiquitin-specific protease 19 that is involved in the differentiation of myogenin and myosin heavy chain. This article presents highlights from the development of drugs that have shown potential in the treatment of wasting disorders, particularly the ghrelin receptor agonist anamorelin, the myostatin antagonist REGN1033, the selective androgen receptor modulators enobosarm and TEI-E0001, and the anabolic catabolic transforming agent espindolol. In addition, novel data on the prevalence and detection methods of muscle wasting/sarcopenia are presented, including the D3-creatine dilution method and several new biomarkers.
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影响因子：
39.3
作者：
Fuelster, Susann;Tacke, Matthias;von Haehling, Stephan
通讯作者：
von Haehling, Stephan
影响因子：
8.9
作者：
Ebner, Nicole;Werner, Claudia G.;Doehner, Wolfram;Anker, Stefan D.;von Haehling, Stephan
通讯作者：
von Haehling, Stephan
影响因子：
8.9
作者：
Coats, Andrew J. Stewart;Srinivasan, Venkatesan;Anker, Stefan D.
通讯作者：
Anker, Stefan D.
影响因子：
3.9
作者：
Hettwer, Stefan;Dahinden, Pius;Vrijbloed, Jan Willem
通讯作者：
Vrijbloed, Jan Willem
影响因子：
8.9
作者：
Omlin, Aurelius;Blum, David;Wierecky, Jan;Haile, Sarah R.;Ottery, Faith D.;Strasser, Florian
通讯作者：
Strasser, Florian