Nutrition impact symptoms in advanced cancer patients: frequency and specific interventions, a case-control study.
Nutrition impact symptoms in advanced cancer patients: frequency and specific interventions, a case-control study.
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DOI：
10.1007/s13539-012-0099-x
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发表时间：
2013-03
影响因子：
8.9
通讯作者：
Strasser, Florian
中科院分区：
文献类型：
--
作者：
Omlin, Aurelius;Blum, David;Wierecky, Jan;Haile, Sarah R.;Ottery, Faith D.;Strasser, Florian
非自愿体重减轻（IWL）在晚期癌症患者中很常见，导致抗癌治疗结局和功能受损。癌症恶病质受营养影响症状（NIS）的影响。本研究的目的是探讨晚期患者NIS的频率，并评估由12项NIS检查表指导的具体干预措施。来自门诊营养疲劳诊所的连续患者完成了NIS检查表。NIS检查表是根据文献综述和多专业临床专家共识制定的。进行图表审查，以检测定义的NIS典型干预。在营养疲劳门诊中没有看到的肿瘤门诊患者在年龄、性别和肿瘤方面相匹配，作为对照。在52名营养疲劳门诊患者中，混合癌症人群[2个月内的IWL为5.96%（平均值）]，5种最常见的NIS为味觉和嗅觉改变27%、便秘19%、腹痛14%、吞咽困难12%和上腹痛10%。与对照人群相比，在味觉和嗅觉改变（p = 0.04）、便秘（p = 0.01）、疼痛（p = 0.0001）和疲劳（p = 0.0004）患者中，NIS典型干预存在统计学显著差异[混合癌，2个月内3.53% IWL（平均值）]。NIS在晚期癌症患者中很常见。NIS清单可以指导针对治疗性营养干预措施。对NIS的认识可能会引起更多的研究在评估，影响和治疗。
Involuntary weight loss (IWL) is frequent in advanced cancer patients causing compromised anticancer treatment outcomes and function. Cancer cachexia is influenced by nutrition impact symptoms (NIS). The aim of this study was to explore the frequency of NIS in advanced patients and to assess specific interventions guided by a 12-item NIS checklist. Consecutive patients from an outpatient nutrition-fatigue clinic completed the NIS checklist. The NIS checklist was developed based on literature review and multiprofessional clinical expert consensus. Chart review was performed to detect defined NIS typical interventions. Oncology outpatients not seen in the nutrition-fatigue clinic were matched for age, sex, and tumor to serve as controls. In 52 nutrition-fatigue clinic patients, a mixed cancer population [IWL in 2 months 5.96 % (mean)], the five most frequent NIS were taste and smell alterations 27 %, constipation 19 %, abdominal pain 14 %, dysphagia 12 %, and epigastric pain 10 %. A statistically significant difference for NIS typical interventions in patients with taste and smell alterations (p = 0.04), constipation (p = 0.01), pain (p = 0.0001), and fatigue (p = 0.0004) were found compared to the control population [mixed cancer, 3.53 % IWL in 2 months (mean)]. NIS are common in advanced cancer patients. The NIS checklist can guide therapeutic nutrition-targeted interventions. The awareness for NIS will likely evoke more research in assessment, impact, and treatment.
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影响因子：
8.8
作者：
通讯作者：
--
DOI：
10.1002/hed.21174
发表时间：
2010-03-01
影响因子：
2.9
作者：
Kubrak, Catherine;Olson, Kaerin;Baracos, Vickie E.
通讯作者：
Baracos, Vickie E.
影响因子：
4.4
作者：
Strasser, F.;Binswanger, J.;Kesselring, A.
通讯作者：
Kesselring, A.
DOI：
10.1097/spc.0b013e32834c4a05
发表时间：
2011-12-01
影响因子：
2.1
作者：
Blum, David;Strasser, Florian
通讯作者：
Strasser, Florian
DOI：
10.1002/hed.20221
发表时间：
2005-08-01
影响因子：
2.9
作者：
Ravasco, P;Monteiro-Grillo, I;Camilo, ME
通讯作者：
Camilo, ME