Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation
Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation
复制标题
迷走神经刺激通过调节谷胱甘肽的产生和转化减轻肝脏缺血和再灌注损伤
DOI：
10.1155/2020/1079129
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Qifa Ye
中科院分区：
文献类型：
--
作者：
Haoyang Xia;Zhongzhong Liu;Wenjin Liang;Xianpeng Zeng;Yi Yang;Pu Chen;Zibiao Zhong;Qifa Ye
炎症和氧化应激是缺血再灌注损伤（IRI）发病机制的关键环节。迷走神经刺激（VNS）可能参与维持氧化稳态以及对外部刺激或损伤的反应。我们……（最后一个单词“inve”似乎不完整）
Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We investigated whether the in vivo VNS can protect the liver from IRI. In this study, hepatic IRI were induced by ligating the vessels supplying the left and middle lobes of the liver, which underwent 1 h occlusion followed with 24 h reperfusion. VNS was initiated 15 min after ischemia and continued 30 min. Hepatic function, histology, and apoptosis rates were evaluated after 24 h reperfusion. Compared with the IRI group, VNS significantly improved hepatic function. The protective effect was accompanied by a reduction in histological damage in the ischemic area, and the apoptosis rate of hepatocytes has considerable reduction. To find the underlying mechanism, proteomic analysis was performed and differential expression of glutathione synthetase (GSS) and glutathione S-transferase (GST) was observed. Subsequently, test results indicated that VNS upregulated the expression of mRNA and protein of GSS and GST. Meanwhile, VNS increased the plasma levels of glutathione and glutathione peroxidases. We found that VNS alleviated hepatic IRI by upregulating the antioxidant glutathione via the GSS/glutathione/GST signaling pathway.
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影响因子：
81.5
作者：
Llovet, Josep M.;Zucman-Rossi, Jessica;Gores, Gregory
通讯作者：
Gores, Gregory
影响因子：
25.7
作者：
Liu, Yuanxing;Ji, Haofeng;Zhang, Yu;Shen, Xiuda;Gao, Feng;He, Xiangyi;Li, Gabriella A.;Busuttil, Ronald W.;Kuchroo, Vijay K.;Kupiec-Weglinski, Jerzy W.
通讯作者：
Kupiec-Weglinski, Jerzy W.
单个迷走神经刺激会降低餐后的早期C肽水平，但不能降低其他激素或餐后代谢。
影响因子：
3.4
作者：
Tang MW;van Nierop FS;Koopman FA;Eggink HM;Gerlag DM;Chan MW;Zitnik R;Vaz FM;Romijn JA;Tak PP;Soeters MR
通讯作者：
Soeters MR
影响因子：
20.1
作者：
Conklin DJ;Guo Y;Jagatheesan G;Kilfoil PJ;Haberzettl P;Hill BG;Baba SP;Guo L;Wetzelberger K;Obal D;Rokosh DG;Prough RA;Prabhu SD;Velayutham M;Zweier JL;Hoetker JD;Riggs DW;Srivastava S;Bolli R;Bhatnagar A
通讯作者：
Bhatnagar A
缺血性中风中的迷走神经刺激：新瓶中的旧酒。
影响因子：
3.4
作者：
Cai PY;Bodhit A;Derequito R;Ansari S;Abukhalil F;Thenkabail S;Ganji S;Saravanapavan P;Shekar CC;Bidari S;Waters MF;Hedna VS
通讯作者：
Hedna VS