Viral respiratory tract infections and asthma: the course ahead.

Viral respiratory tract infections and asthma: the course ahead.
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DOI:
10.1016/j.jaci.2010.04.002
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发表时间:
2010-06
影响因子:
14.2
通讯作者:
Gern, James E.
Gern, James E.
中科院分区:
医学1区
文献类型:
--
作者:
Rosenthal, Louis A.;Avila, Pedro C.;Heymann, Peter W.;Martin, Richard J.;Miller, E. Kathryn;Papadopoulos, Nikolaos G.;Peebles, R. Stokes, Jr.;Gern, James E.

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研究方法和技术的最新进展正在促进对病毒性呼吸道疾病与哮喘的开始和恶化之间关系的调查。在本文中,我们确定了重要的知识缺口和未来的研究问题,并讨论了新的研究工具,包括改进的呼吸道病毒检测技术,将如何允许当前和未来的研究人员定义这些关系以及调节它们的宿主、病毒、发育和环境机制。更好地了解这些过程应有助于制定预防和治疗病毒引起的喘息疾病和哮喘加重的改进策略,并可能实现发现哮喘初级预防的有效方法的最终目标。
Inquiries into the relationships between viral respiratory tract illnesses and the inception and exacerbation of asthma are being facilitated by recent advances in research approaches and technology. In this article we identify important knowledge gaps and future research questions, and we discuss how new investigational tools, including improved respiratory tract virus detection techniques, will permit current and future researchers to define these relationships and the host, virus, developmental, and environmental mechanisms that regulate them. A better understanding of these processes should facilitate the development of improved strategies for the prevention and treatment of virus-induced wheezing illnesses and asthma exacerbations and, possibly, the ultimate goal of discovering effective approaches for the primary prevention of asthma.
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