A novel group of rhinoviruses is associated with asthma hospitalizations.
A novel group of rhinoviruses is associated with asthma hospitalizations.
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DOI：
10.1016/j.jaci.2008.10.007
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
New Vaccine Surveillance Network
中科院分区：
文献类型：
--
作者：
Miller EK;Edwards KM;Weinberg GA;Iwane MK;Griffin MR;Hall CB;Zhu Y;Szilagyi PG;Morin LL;Heil LH;Lu X;Williams JV;New Vaccine Surveillance Network
虽然最近的研究已经确定了新的C组人鼻病毒（HRVC），但其儿科疾病谱尚不清楚。我们试图确定HRVC引起的住院儿童疾病的表现和负担。我们对2001年10月至2003年9月因急性呼吸道疾病或发热住院的5岁以下儿童进行了前瞻性人群监测。获得鼻/喉拭子并检测HRV，通过RT-PCR测定，然后通过部分测序进行表征。1052名儿童登记和测试在2年期间，167（16%）有HRV检测。成功测序的147份样本中，64份为A组HRV，6份为B组HRV，77份为HRVC。与A组HRV相比，HRVC儿童更有可能患有潜在的高危疾病，如哮喘（42% vs 23%，P = 0.023）和出院诊断为哮喘（55% vs 36%，P = 0.022）。总体而言，在7%因发热或呼吸系统疾病住院的儿童中检测到HRVC，占所有鼻病毒相关住院的近一半，这表明这一新群体造成了儿科疾病的巨大负担。
Although recent studies have identified new group C human rhinoviruses (HRVCs), their spectrum of pediatric disease is unknown. We sought to determine the presentation and burden of disease caused by HRVCs among young hospitalized children. We conducted prospective population-based surveillance in 2 US counties among children less than 5 years of age hospitalized with acute respiratory illness or fever from October 2001 through September 2003. Nasal/throat swabs were obtained and tested for HRVs, as determined by means of RT-PCR and then characterized by means of partial sequencing. Of 1052 children enrolled and tested during the 2-year period, 167 (16%) had HRVs detected. Of 147 samples successfully sequenced, 64 were group A HRVs, 6 were group B HRVs, and 77 were HRVCs. Children with HRVCs were significantly more likely than those with group A HRVs to have underlying high-risk conditions, such as asthma (42% vs 23%, P = .023) and to have had a discharge diagnosis of asthma (55% vs 36%, P = .022). Overall, HRVCs were detected in 7% of children hospitalized for fever or respiratory conditions and constituted almost half of all rhinovirus-associated hospitalizations, suggesting that this novel group causes a substantial burden of pediatric disease.
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影响因子：
9.4
作者：
Erdman, DD;Weinberg, GA;Anderson, LJ
通讯作者：
Anderson, LJ
影响因子：
3.1
作者：
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通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
KAPIKIAN A Z
影响因子：
8
作者：
Iwane, MK;Edwards, KM;Schwartz, B
通讯作者：
Schwartz, B