Beta and Gamma Human Herpesviruses: Agonistic and Antagonistic Interactions with the Host Immune System.
Beta and Gamma Human Herpesviruses: Agonistic and Antagonistic Interactions with the Host Immune System.
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DOI：
10.3389/fmicb.2017.02521
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发表时间：
2017
影响因子：
5.2
通讯作者：
Fuentes-Pananá EM
中科院分区：
文献类型：
--
作者：
Cruz-Muñoz ME;Fuentes-Pananá EM
病毒是地球上最丰富多样的生物实体。从历史上看，我们对病毒的主要兴趣集中在它们的致病作用上，这一点在导致世界人口大量减少的大流行病中得到了承认。然而，病毒感染也在细胞生物体的进化中发挥了重要作用，无论是通过交换具有新功能的基因还是塑造免疫系统。感染的例子比比皆是，严重损害主机的完整性，但植物和昆虫病毒互惠关系的证据最近浮出水面，其中受感染的主机更适合生存，认为病毒-主机的相互作用最初是寄生的，但多年的共同进化成为互惠。肠道细菌也出现了类似的互助情景。EBV是一种疱疹病毒，与人类共同进化了一亿多年，今天成功感染了近100%的成年世界人口。感染通常在儿童早期获得，持续宿主一生，大多没有明显的临床症状。这种稳态的紊乱是罕见的，并导致几种疾病，其中最好的理解是传染性单核细胞增多症和几种EBV相关的癌症。较少了解的是最近发现的先天性免疫系统缺陷，导致原发性免疫缺陷，几乎只与EBV相关疾病的易感性增加。令人困惑的是，这些破坏稳态的情况是免疫抑制、炎症、自身免疫和癌症的共存。与EBV、HCMV、HHV-6和HHV-7同源的疱疹病毒也潜伏感染大多数个体。几条证据支持HCMV/EBV和宿主之间的互利平衡，当改变时触发免疫系统发挥关键作用的疾病。有趣的是，这些β和γ疱疹病毒持续感染所有免疫谱系和早期前体细胞。在这篇综述中，我们将讨论这些疱疹病毒感染免疫细胞给宿主带来益处的证据。此外，这种积极的关系被打破的情况下，易诱发宿主的疾病，其特征是宿主免疫系统的功能异常。
Viruses are the most abundant and diverse biological entities in the planet. Historically, our main interest in viruses has focused on their pathogenic role, recognized by pandemics that have decimated the world population. However, viral infections have also played a major role in the evolution of cellular organisms, both through interchanging of genes with novel functions and shaping the immune system. Examples abound of infections that seriously compromise the host integrity, but evidence of plant and insect viruses mutualistic relationships have recently surfaced in which infected hosts are better suited for survival, arguing that virus-host interactions are initially parasitic but become mutualistic over years of co-evolution. A similar mutual help scenario has emerged with commensal gut bacteria. EBV is a herpesvirus that shares more than a hundred million years of co-evolution with humans, today successfully infecting close to 100% of the adult world population. Infection is usually acquired early in childhood persisting for the host lifetime mostly without apparent clinical symptoms. Disturbance of this homeostasis is rare and results in several diseases, of which the best understood are infectious mononucleosis and several EBV-associated cancers. Less understood are recently found inborn errors of the immune system that result in primary immunodeficiencies with an increased predisposition almost exclusive to EBV-associated diseases. Puzzling to these scenarios of broken homeostasis is the co-existence of immunosuppression, inflammation, autoimmunity and cancer. Homologous to EBV, HCMV, HHV-6 and HHV-7 are herpesviruses that also latently infect most individuals. Several lines of evidence support a mutualistic equilibrium between HCMV/EBV and hosts, that when altered trigger diseases in which the immune system plays a critical role. Interestingly, these beta and gamma herpesviruses persistently infect all immune lineages and early precursor cells. In this review, we will discuss the evidence of the benefits that infection of immune cells with these herpesviruses brings to the host. Also, the circumstances in which this positive relationship is broken, predisposing the host to diseases characterized by an abnormal function of the host immune system.
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DOI：
10.1084/jem.20130592
发表时间：
2013-08-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Byun M;Ma CS;Akçay A;Pedergnana V;Palendira U;Myoung J;Avery DT;Liu Y;Abhyankar A;Lorenzo L;Schmidt M;Lim HK;Cassar O;Migaud M;Rozenberg F;Canpolat N;Aydogan G;Fleckenstein B;Bustamante J;Picard C;Gessain A;Jouanguy E;Cesarman E;Olivier M;Gros P;Abel L;Croft M;Tangye SG;Casanova JL
通讯作者：
Casanova JL
影响因子：
4.4
作者：
Arens, R;Baars, PA;van Lier, RAW
通讯作者：
van Lier, RAW
DOI：
10.1084/jem.20101597
发表时间：
2010-10-25
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Byun M;Abhyankar A;Lelarge V;Plancoulaine S;Palanduz A;Telhan L;Boisson B;Picard C;Dewell S;Zhao C;Jouanguy E;Feske S;Abel L;Casanova JL
通讯作者：
Casanova JL
影响因子：
20.3
作者：
Bryceson, Yenan T.;Pende, Daniela;Ehl, Stephan
通讯作者：
Ehl, Stephan
DOI：
10.1196/annals.1422.059
发表时间：
2007-01-01
期刊：
AUTOIMMUNITY, PT D
影响因子：
--
作者：
Barzilai, O.;Sherer, Y.;Shoenfeld, Y.
通讯作者：
Shoenfeld, Y.