Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort.
Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort.
复制标题
DOI：
10.1016/j.jad.2016.06.049
复制
发表时间：
2016-11-01
影响因子：
6.6
通讯作者：
Ebmeier KP
中科院分区：
文献类型：
--
作者：
Allan CL;Sexton CE;Filippini N;Topiwala A;Mahmood A;Zsoldos E;Singh-Manoux A;Shipley MJ;Kivimaki M;Mackay CE;Ebmeier KP
晚年阈下抑郁症状（即不符合重度抑郁症诊断标准的抑郁症状）与身体健康和功能受损以及重度抑郁症风险增加有关。磁共振成像（MRI）研究检查晚年重度抑郁症发现大脑结构的变化，在灰色和白色物质。然而，晚年阈下抑郁症与类似特征的相关程度还没有得到很好的确定。从白厅成像子研究中选择无重度抑郁症病史的参与者（n=358，平均年龄69±5岁，17%为女性）。使用流行病学研究中心抑郁量表（CES-D）在前三个白厅II研究阶段（2003-04，2007-09和2012-13）和MRI扫描时（2012-14）测量抑郁症状。当前和累积抑郁症状和MRI脑测量之间的关系进行了探讨，使用基于体素的形态学（VBM）的灰质和基于道的空间统计（TBSS）的白色物质。当前阈下抑郁症状与各向异性分数的显著降低以及轴向和径向扩散率的增加相关。目前的抑郁症状和灰质措施，或累积抑郁症状和MRI测量之间没有显着的关系。亚阈值抑郁症状的流行率（10%）意味着分析可能无法检测大脑结构的细微差异。目前的阈下抑郁症状与白色物质微结构的变化有关，表明即使是轻度抑郁症状也与重度抑郁症的MRI特征相似。本研究调查了社区样本中的阈下抑郁症状。抑郁症状在11年中被测量了4次。脑MRI变量检查灰质体积和白色物质显微结构。目前的抑郁症状与白色物质完整性降低有关。阈下症状显示出与重度抑郁症相似的MRI特征。
Late-life sub-threshold depressive symptoms (i.e. depressive symptoms that do not meet the criteria for a diagnosis of major depressive disorder) are associated with impaired physical health and function, and increased risk of major depressive disorder. Magnetic resonance imaging (MRI) studies examining late-life major depressive disorder find structural brain changes in grey and white matter. However, the extent to which late-life sub-threshold depression is associated with similar hallmarks is not well established. Participants with no history of major depressive disorder were selected from the Whitehall Imaging Sub-Study (n=358, mean age 69±5 years, 17% female). Depressive symptoms were measured using the Centre for Epidemiological Studies Depression Scale (CES-D) at three previous Whitehall II Study phases (2003–04, 2007–09 and 2012–13) and at the time of the MRI scan (2012–14). The relationships between current and cumulative depressive symptoms and MRI brain measures were explored using Voxel-Based Morphometry (VBM) for grey matter and Tract Based Spatial Statistics (TBSS) for white matter. Current sub-threshold depressive symptoms were associated with significant reductions in fractional anisotropy and increases in axial and radial diffusivity. There were no significant relationships between current depressive symptoms and grey matter measures, or cumulative depressive symptoms and MRI measures. The prevalence (10%) of sub-threshold depressive symptoms means that analyses may be underpowered to detect subtle differences in brain structure. Current sub-threshold depressive symptoms are associated with changes in white matter microstructure, indicating that even mild depressive symptoms are associated with similar MRI hallmarks to those in major depressive disorder. This study investigated sub-threshold depressive symptoms in a community sample. Depressive symptoms were measured 4 times over 11 years. Brain MRI variables examined grey matter volume and white matter microstructure. Current depressive symptoms were associated with reduced white matter integrity. Sub-threshold symptoms show similar MRI hallmarks to major depressive disorder.
登录
查看更多内容
DOI：
10.3233/jad-2012-112009
发表时间：
2012
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Geerlings MI;Brickman AM;Schupf N;Devanand DP;Luchsinger JA;Mayeux R;Small SA
通讯作者：
Small SA
影响因子：
--
作者：
Sexton, Claire E.;Allan, Charlotte L.;Ebmeier, Klaus P.
通讯作者：
Ebmeier, Klaus P.
影响因子：
4.8
作者：
Smith, SM
通讯作者：
Smith, SM
DOI：
10.1097/01.jgp.0000235763.50230.83
发表时间：
2007-03-01
影响因子：
7.2
作者：
Lyness, Jeffrey M.;Kim, JaeHyun;Caine, Eric D.
通讯作者：
Caine, Eric D.
影响因子：
10.5
作者：
Sexton, Claire E.;Le Masurier, Marisa;Ebmeier, Klaus P.
通讯作者：
Ebmeier, Klaus P.