The Catabolism of 4-Hydroxyacetophenone by an Alcaligenes sp.
The Catabolism of 4-Hydroxyacetophenone by an Alcaligenes sp.
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产碱菌对 4-羟基苯乙酮的分解代谢。
DOI：
10.1099/00221287-131-7-1807
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发表时间：
1985
期刊：
影响因子：
1.5
通讯作者：
M. Rhodes
中科院分区：
文献类型：
--
作者：
D. Hopper;H. Jones;E. A. Elmorsi;M. Rhodes
Summary: A bacterium capable of growth on 4-hydroxyacetophenone was isolated from soil and identified as an Alcaligenes sp. Intact cells rapidly oxidized (4-hydroxybenzoyl)methanol, 4-hydroxybenzoate and protocatechuate as well as the growth substrate, and also converted the substrate analogue (4-methoxybenzoyl)methanol to 4-methoxybenzoic acid. When provided with NADH, cell-free extracts oxidized 4-hydroxyacetophenone to 4-hydroxybenzoate and formate, the same products as were formed from (4-hydroxybenzoyl)methanol without NADH. The oxidation of 4-hydroxybenzoate by cell-free extracts required NADPH and the product from both this and protocatechuate oxidation was 3-oxoadipate. A pathway for the catabolism of 4-hydroxyacetophenone, by hydroxylation to (4-hydroxybenzoyl)methanol followed by oxidative cleavage to 4-hydroxybenzoate and formate and hydroxylation of the 4-hydroxybenzoate to protocatechuate, is proposed. Oxidation of protocatechuate was by the ortho pathway. The key enzymes in the proposed pathway were induced by growth on 4-hydroxyacetophenone.
对甲酚甲基羟化酶将 4-乙基苯酚羟基化产生 1-(4-羟基苯基)乙醇的立体化学。
DOI：
10.1042/bj2240617
发表时间：
1984
期刊：
The Biochemical journal
影响因子：
--
作者：
McIntire,W;Hopper,DJ;Craig,JC;Everhart,ET;Webster,RV;Causer,MJ;Singer,TP
通讯作者：
Singer,TP