Caenorhabditis elegans as an Infection Model for Pathogenic Mold and Dimorphic Fungi: Applications and Challenges.
Caenorhabditis elegans as an Infection Model for Pathogenic Mold and Dimorphic Fungi: Applications and Challenges.
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DOI：
10.3389/fcimb.2021.751947
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发表时间：
2021
影响因子：
5.7
通讯作者：
Fang W
中科院分区：
文献类型：
--
作者：
Ahamefule CS;Ezeuduji BC;Ogbonna JC;Moneke AN;Ike AC;Jin C;Wang B;Fang W
病原性真菌的威胁负担是普遍的，并且随着侵袭性真菌感染的死亡率和发病率惊人地高而不断增加。了解这些真菌的毒力因子，筛选有效的抗真菌药物，并在体内模拟生物中探索合适的治疗方法是控制真菌病的重要研究项目。秀丽隐杆线虫已被证明是一个有价值的工具，在大多数临床相关的二型真菌的研究，有助于确定一些毒力因子和免疫调节剂，并筛选有效的抗真菌药物，没有细胞毒性作用。然而，关于线虫模型中的致病性丝状真菌（霉菌），几乎没有取得和报道。本文综述了C. elegans感染模型用于二型真菌的研究，丝状真菌的报道很少。我们还确定并讨论了C中的挑战。优雅的模具建模应用程序，以及可能的方法来克服这些挑战，从我们的实际知识在C。elegans-Aspergillus fumigatus模型。
The threat burden from pathogenic fungi is universal and increasing with alarming high mortality and morbidity rates from invasive fungal infections. Understanding the virulence factors of these fungi, screening effective antifungal agents and exploring appropriate treatment approaches in in vivo modeling organisms are vital research projects for controlling mycoses. Caenorhabditis elegans has been proven to be a valuable tool in studies of most clinically relevant dimorphic fungi, helping to identify a number of virulence factors and immune-regulators and screen effective antifungal agents without cytotoxic effects. However, little has been achieved and reported with regard to pathogenic filamentous fungi (molds) in the nematode model. In this review, we have summarized the enormous breakthrough of applying a C. elegans infection model for dimorphic fungi studies and the very few reports for filamentous fungi. We have also identified and discussed the challenges in C. elegans-mold modeling applications as well as the possible approaches to conquer these challenges from our practical knowledge in C. elegans-Aspergillus fumigatus model.
影响因子：
3.7
作者：
Regulin A;Kempken F
通讯作者：
Kempken F