Oncogenomic Approaches in Exploring Gain of Function of Mutant p53.
Oncogenomic Approaches in Exploring Gain of Function of Mutant p53.
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DOI：
10.2174/138920208784340713
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发表时间：
2008-05
期刊：
影响因子：
2.6
通讯作者：
Blandino G
中科院分区：
文献类型：
--
作者：
Donzelli S;Biagioni F;Fausti F;Strano S;Fontemaggi G;Blandino G
癌症是由特定细胞基因组中的变化在空间和时间上积累引起的。这导致了对在控制细胞增殖和细胞命运中发挥关键作用的关键信号通路的放松管制。P53抑癌基因是人类癌症基因改变中最常见的靶点。这种突变的主要选择优势是消除细胞野生型P53活性。此外，体外和体内的许多证据表明，至少某些突变型的p53可能具有功能增强，从而对癌症的进展起到积极的作用。对特定癌症表型的精细绘制和破译正在利用基于全基因组方法的分子图谱研究。目前，基于阵列的比较基因组杂交(CGH阵列)、单核苷酸多态阵列(SNP阵列)、表达阵列和芯片阵列等高通量方法可用于研究人类癌症中突变的p53相关改变。在这里，我们将主要集中在整合通过癌基因组平台提出的结果，旨在阐明突变型p53获得功能活性的分子机制，并为肿瘤患者的分子分层提供有用的信息。
Cancer is caused by the spatial and temporal accumulation of alterations in the genome of a given cell. This leads to the deregulation of key signalling pathways that play a pivotal role in the control of cell proliferation and cell fate. The p53 tumor suppressor gene is the most frequent target in genetic alterations in human cancers. The primary selective advantage of such mutations is the elimination of cellular wild type p53 activity. In addition, many evidences in vitro and in vivo have demonstrated that at least certain mutant forms of p53 may possess a gain of function, whereby they contribute positively to cancer progression. The fine mapping and deciphering of specific cancer phenotypes is taking advantage of molecular-profiling studies based on genome-wide approaches. Currently, high-throughput methods such as array-based comparative genomic hybridization (CGH array), single nucleotide polymorphism array (SNP array), expression arrays and ChIP-on-chip arrays are available to study mutant p53-associated alterations in human cancers. Here we will mainly focus on the integration of the results raised through oncogenomic platforms that aim to shed light on the molecular mechanisms underlying mutant p53 gain of function activities and to provide useful information on the molecular stratification of tumor patients.
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影响因子：
56.9
作者：
CHO, YJ;GORINA, S;PAVLETICH, NP
通讯作者：
PAVLETICH, NP
影响因子：
14.9
作者：
Göhler T;Jäger S;Warnecke G;Yasuda H;Kim E;Deppert W
通讯作者：
Deppert W
影响因子：
8
作者：
Blandino, G;Levine, AJ;Oren, M
通讯作者：
Oren, M
影响因子：
3.3
作者：
Chen, X;Cheung, ST;Brown, PO
通讯作者：
Brown, PO
DOI：
10.1186/bcr1675
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Langerød A;Zhao H;Borgan Ø;Nesland JM;Bukholm IR;Ikdahl T;Kåresen R;Børresen-Dale AL;Jeffrey SS
通讯作者：
Jeffrey SS