Extracellular vesicles: pathogenic messengers and potential therapy for neonatal lung diseases.
Extracellular vesicles: pathogenic messengers and potential therapy for neonatal lung diseases.
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DOI：
10.3389/fped.2023.1205882
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发表时间：
2023
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞外囊泡（EV）是一组异质的纳米尺寸膜结构，越来越多地被认为是细胞间和器官间通讯的介质。 EV 含有蛋白质、脂质和核酸，其成分高度依赖于亲本细胞的生物学功能。它们的货物受到磷脂膜的保护，免受细胞外环境的影响，从而可以将完整的货物安全运输和递送到附近或远处的靶细胞，从而改变靶细胞的基因表达、信号通路和整体功能。 EV 具有高度选择性、复杂的网络，通过 EV 促进细胞信号传导和调节细胞过程，使得研究 EV 成为了解各种生物功能和疾病机制的主要兴趣焦点。气管吸出物 EV-miRNA 分析已被建议作为早产儿呼吸结局的潜在生物标志物，并且有强有力的临床前证据表明，干细胞释放的 EV 可以保护发育中的肺部免受高氧和感染的有害影响。本文将回顾 EV 作为新生儿肺部疾病的致病信使、生物标志物和潜在疗法的作用。
Extracellular vesicles (EVs) are a heterogeneous group of nano-sized membranous structures increasingly recognized as mediators of intercellular and inter-organ communication. EVs contain a cargo of proteins, lipids and nucleic acids, and their cargo composition is highly dependent on the biological function of the parental cells. Their cargo is protected from the extracellular environment by the phospholipid membrane, thus allowing for safe transport and delivery of their intact cargo to nearby or distant target cells, resulting in modification of the target cell's gene expression, signaling pathways and overall function. The highly selective, sophisticated network through which EVs facilitate cell signaling and modulate cellular processes make studying EVs a major focus of interest in understanding various biological functions and mechanisms of disease. Tracheal aspirate EV-miRNA profiling has been suggested as a potential biomarker for respiratory outcome in preterm infants and there is strong preclinical evidence showing that EVs released from stem cells protect the developing lung from the deleterious effects of hyperoxia and infection. This article will review the role of EVs as pathogenic messengers, biomarkers, and potential therapies for neonatal lung diseases.
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DOI：
10.1002/wnan.1835
发表时间：
2023-01
期刊：
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.4
作者：
Deregibus MC;Figliolini F;D'Antico S;Manzini PM;Pasquino C;De Lena M;Tetta C;Brizzi MF;Camussi G
通讯作者：
Camussi G
影响因子：
64.8
作者：
Fukuda, R;McNew, JA;Söllner, TH
通讯作者：
Söllner, TH
影响因子：
10.8
作者：
Aliotta, Jason M.;Pereira, Mandy;Klinger, James R.
通讯作者：
Klinger, James R.
影响因子：
6
作者：
Aliotta JM;Pereira M;Wen S;Dooner MS;Del Tatto M;Papa E;Cheng Y;Goldberg L;Ventetuolo CE;Liang O;Klinger JR;Quesenberry PJ
通讯作者：
Quesenberry PJ