Functional associations between collagen fibre orientation and locomotor strain direction in cortical bone of the equine radius
Functional associations between collagen fibre orientation and locomotor strain direction in cortical bone of the equine radius
复制标题
马桡骨皮质骨胶原纤维取向与运动应变方向之间的功能关联
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Alan Boyde
中科院分区：
文献类型：
--
作者：
Christopher M. Riggs;Lance E. Lanyon;Alan Boyde
用一种新的技术测定皮质骨横切面的胶原纤维取向模式，以研究马的桡骨的骨干中段切片。几项活体应变计研究已经证明，在运动过程中，这种骨骼是弯曲的，因此头骨皮质始终受到纵向拉伸应变的影响，尾部皮质受到纵向压缩应变的影响。对17匹马的23条半月板进行了研究。所有从成年马获得的骨骼在皮质上都显示出一致的胶原纤维取向模式。承受间歇性张力的颅骨皮质，以及中性轴通过的外侧和内侧皮质，主要含有纵向取向的胶原纤维。尾侧皮质在生命过程中受到纵向挤压，主要含有斜/横向胶原。这种模式在马驹的骨骼中不太明显。对所研究的骨骼进行的显微镜分析表明，初级板层骨主要由纵向胶原纤维组成，与皮质无关。然而，在重塑的骨中，皮质位置和纤维方向之间有很强的关系。在尾侧(受压)皮质形成的次生骨主要含有斜/横向胶原，而在其他部位形成的次级骨主要含有纵向胶原。这一观察解释了成人整个皮质胶原纤维取向的特征宏观模式的发育外观。这些发现为骨骼的机械功能与其结构之间的关系的存在提供了证据，现在证明了它延伸到了分子水平。
A novel technique for determining the collagen fibre orientation pattern of cross-sections of cortical bone was used to study mid-diaphyseal sections from the equine radius. Several in vivo strain gauge studies have demonstrated that this bone is loaded in bending during locomotion in such a way that the cranial cortex is consistently subjected to longitudinal tensile strains and the caudal cortex to longitudinal compressive strains. Twenty-three radii from 17 horses were studied. All the bones obtained from adult horses exhibited a consistent pattern of collagen fibre orientation across the cortex. The cranial cortex, subjected to intermittent tension, and the lateral and medial cortices, through which the neutral axis passes, contained predominantly longitudinally oriented collagen fibres. The caudal cortex, subjected to longitudinal compression during life, contained predominantly oblique/transverse collagen. This pattern was less evident in bones from foals. Microscopic analysis of the bones studied showed that primary lamellar bone was composed of predominantly longitudinal collagen fibres, irrespective of cortex. However, there was a strong relationship between cortical location and fibre orientation within remodelled bone. Secondary osteons which formed in the caudal (compressive) cortex contained predominantly oblique/transverse collagen, while those which formed elsewhere contained longitudinal collagen. This observation explained the developmental appearance of the characteristic macroscopic pattern of collagen fibre orientation across the whole cortex in the adult. These findings provide evidence for the existence of a relationship between the mechanical function of a bone with its architecture, and now demonstrate that it extends to the molecular level.
影响因子：
2.4
作者：
BIEWENER, AA;THOMASON, J;LANYON, LE
通讯作者：
LANYON, LE
影响因子：
3.5
作者：
Sansalone, Vittorio;Kaiser, Joanna;Lemaire, Thibault
通讯作者：
Lemaire, Thibault