Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis.
Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis.
复制标题
DOI：
10.3390/ijms18112312
复制
发表时间：
2017-11-02
影响因子：
5.6
通讯作者：
Adachi N
中科院分区：
文献类型：
--
作者：
Numakawa T;Odaka H;Adachi N
改变的神经发生被认为与脑疾病的发病有关，包括精神障碍和神经退行性疾病。神经营养因子对胚胎和成体神经干/祖细胞（NSCs/NPCs）的增殖/分化具有积极作用。尤其是脑源性神经营养因子（brain-derived neurotrophic factor，BDNF），由于其在神经干细胞/神经前体细胞的分化/成熟中的作用而受到广泛的研究。另一方面，最近的证据表明应激激素糖皮质激素（GC）对NSC/NPCs的细胞命运的负面影响，这也与脑疾病的病理生理学有关，例如抑郁症和自闭症谱系障碍。此外，包括我们在内的研究已经证明了神经营养因子和GC在神经事件（包括神经发生）中的功能相互作用。在这篇综述中，我们显示和讨论的行为之间的关系，神经干细胞/NPC，脑源性神经营养因子，和GCs。
Altered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NSCs/NPCs). Especially, brain-derived neurotrophic factor (BDNF) has been extensively investigated because of its roles in the differentiation/maturation of NSCs/NPCs. On the other hand, recent evidence indicates a negative impact of the stress hormone glucocorticoids (GCs) on the cell fate of NSCs/NPCs, which is also related to the pathophysiology of brain diseases, such as depression and autism spectrum disorder. Furthermore, studies including ours have demonstrated functional interactions between neurotrophic factors and GCs in neural events, including neurogenesis. In this review, we show and discuss relationships among the behaviors of NSCs/NPCs, BDNF, and GCs.
登录
查看更多内容
影响因子：
7.3
作者：
Dai, JP;Buijs, R;Swaab, D
通讯作者：
Swaab, D
影响因子：
25
作者：
Chen, Dillon Y.;Bambah-Mukku, Dhananjay;Pollonini, Gabriella;Alberini, Cristina M.
通讯作者：
Alberini, Cristina M.
影响因子：
7.7
作者：
Gass, P;Kretz, O;Schütz, G
通讯作者：
Schütz, G
影响因子：
1.2
作者：
Gebara, Elias;Udry, Florian;Toni, Nicolas
通讯作者：
Toni, Nicolas
DOI：
10.1038/npp.2012.253
发表时间：
2013-04
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--