Treatment of asthma and food allergy with herbal interventions from traditional chinese medicine.
Treatment of asthma and food allergy with herbal interventions from traditional chinese medicine.
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DOI：
10.1002/msj.20294
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发表时间：
2011-09
影响因子：
--
通讯作者：
Li, Xiu-Min
中科院分区：
文献类型：
--
作者：
Li, Xiu-Min
关键词：
在过去的2- 30年里，哮喘和过敏的患病率在西方国家有所增加。尽管人们对哮喘和过敏性疾病的发病机制有了更多的了解，但严重哮喘的控制仍然很困难。哮喘也与焦虑的高患病率有关，特别是青少年。食物过敏没有有效的治疗方法。食物过敏通常与严重的湿疹有关。迫切需要治疗哮喘、食物过敏和共病的新方法。在亚洲使用了几个世纪的传统中医（TCM）开始在西方医疗保健中发挥作用。越来越多的科学证据支持使用中医药治疗哮喘。这篇综述文章讨论了有前途的中医干预哮喘，食物过敏和共病条件，并探讨其可能的作用机制。自2005年以来，已经发表了几项关于“抗哮喘”草药的对照临床研究。在草药中，抗哮喘草药干预（ASHMI）是唯一一个进入临床试验的美国FDA研究性新药（IND）的抗哮喘中药产品。目前正在积极研究ASHMI在动物模型中的作用和作用机制。治疗食物过敏的中草药研究较少。草药干预，Food Allergy Herbal Formula-2（FAHF-2）是唯一一个正在调查的美国FDA植物IND作为多种食物过敏治疗。已发表的文章和摘要，以及在ASHMI和FAHF-2的临床前和临床研究中产生的新数据是本综述的基础。并结合文献回顾，探讨中医药治疗食物过敏相关湿疹的疗效。实验室和临床研究表明ASHMI治疗对哮喘有有益的效果。潜在的功效的可能机制是多种的。临床前研究证明了FAHF-2治疗小鼠模型食物过敏的有效性和安全性。一项临床研究表明，FAHF-2是安全的，耐受性良好，并表现出有益的免疫调节作用。一项临床报告显示，中医治疗降低了湿疹评分，改善了生活质量。草药干预，ASHMI和FAHF-2可进一步开发为治疗哮喘和食物过敏的植物药。中医也可能对焦虑和湿疹等共病有益。需要更多的对照研究。总之，迫切需要治疗哮喘和食物过敏以及焦虑和湿疹等共病的新方法。本文讨论了有前途的干预措施，从传统中医（TCM），并探讨其可能的作用机制。
Prevalence of asthma and allergy has increased over the past 2–3 decades in Westernized countries. Despite increased understanding of the pathogenesis of asthma and allergic diseases, control of severe asthma is still difficult. Asthma is also associated with high prevalence of anxiety in particular adolescents. There is no effective treatment for food allergy. Food allergy is often associated with severe and recalcitrant eczema. Novel approaches for treatment of asthma and food allergy and comorbid conditions are urgently needed. Traditional Chinese medicine (TCM), used in Asia for centuries, is beginning to play a role in Western health care. There is increasing scientific evidence supporting the use of TCM for asthma treatment. This review article discusses promising TCM interventions for asthma, food allergy and comorbid conditions and explores their possible mechanisms of action. Since 2005, several controlled clinical studies of “anti-asthma” herbal remedies have been published. Among the herbal medicines, anti-asthma herbal medicine intervention (ASHMI) is the only anti-asthma TCM product that is a US FDA investigational new drug (IND) that has entered clinical trials. Research into ASHMI’s effects and mechanisms of actions in animal models is actively being pursued. Research on TCM herbal medicines for treating food allergy is rare. The herbal intervention, Food Allergy Herbal Formula-2 (FAHF-2) is the only US FDA botanical IND under investigation as a multiple food allergy therapy. Published articles and abstracts, as well as new data generated in preclinical and clinical studies of ASHMI and FAHF-2 are the bases for this review. The effect of TCM therapy on food allergy associated recalcitrant eczema, based on case review, is also included. Laboratory and clinical studies demonstrate a beneficial effect of ASHMI treatment on asthma. The possible mechanisms underlying the efficacy are multiple. Preclinical studies demonstrated the efficacy and safety of FAHF-2 for treating food allergy in a murine model. A clinical study demonstrated that FAHF-2 is safe, well tolerated, and exhibited beneficial immunomodulatory effects. A clinical report showed that TCM treatment reduced eczema scores and improved quality of life. Herbal interventions, ASHMI and FAHF-2 may be further developed as botanical drugs for treating asthma and food allergy. TCM may also be of benefit for comorbid conditions such as anxiety and recalcitrant eczema. More controlled studies are warranted. In conclusion, novel approaches for treatment of asthma and food allergy and comorbid conditions such as anxiety and eczema are urgently needed. This article discusses promising interventions for such conditions from traditional Chinese medicine (TCM) and explores their possible mechanisms of action.
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分类哮喘的细胞因子。
影响因子：
15.3
作者：
Drazen, JM;Arm, JP;Austen, KF
通讯作者：
Austen, KF
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14.2
作者：
Bock, SA;Muñoz-Furlong, A;Sampson, HA
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12.4
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Clark, A. T.;Islam, S.;Ewan, P. W.
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Ewan, P. W.
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3.4
作者：
Ebo, D. G.;Hagendorens, M. M.;Stevens, W. J.
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Stevens, W. J.
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8
作者：
Akinbami, Lara J.;Moorman, Jeanne E.;Sondik, Edward J.
通讯作者：
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