LncRNAs as biomarkers for predicting radioresistance and survival in cancer: a meta-analysis.
LncRNAs as biomarkers for predicting radioresistance and survival in cancer: a meta-analysis.
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LncRNA 作为预测癌症放射抗性和生存的生物标志物：一项荟萃分析
DOI：
10.1038/s41598-022-21785-1
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发表时间：
2022-11-02
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
长非编码RNA(LncRNAs)对放射治疗疗效的影响已逐渐被发现。本综述和荟萃分析旨在评价lncRNAs在调节不同肿瘤的放射敏感性和放射抵抗中的功能和潜在机制之间的联系。计算风险比(HR)和相应的95%可信区间(CI)，以评估LncRNAs对癌症患者预后的影响，包括总生存期(OS)、无复发生存期(RFS)、无病生存期(DFS)和无进展生存期(PFS)。总共登记了11种癌症类型的23个LncRNA。其中，13个lncRNAs表达下调与放射敏感性相关，11个lncRNAs上调与辐射抗性相关，3个lncRNAs上调与肿瘤放射敏感性相关。此外，在这项荟萃分析中，17个microRNAs和20个通路被不同的lncRNAs靶向，并与癌症的放射治疗反应有关。下调的抗辐射和上调的抗辐射LncRNAs的个体合计比例(95%顺式)分别为0.49(0.40~0.60)和1.88(1.26~2.79)。我们的结果表明，lncRNAs可以通过影响与辐射相关的信号通路来调节肿瘤的辐射抵抗或敏感性，并作为预测放射治疗疗效的潜在生物标志物。
The effect of long noncoding RNAs (lncRNAs) on the radiotherapy response has been gradually revealed. This systematic review and meta-analysis aimed to evaluate the association between the function and underlying mechanism of lncRNAs in regulating the radiosensitivity and radioresistance of different tumors. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were calculated to estimate the effect of lncRNAs on cancer patient prognosis, including overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS) and progression-free survival (PFS). Collectively, 23 lncRNAs in 11 cancer types were enrolled. Of them, 13 lncRNAs were downregulated and related to radiosensitivity, 11 lncRNAs were upregulated and related to radioresistance, and 3 lncRNAs were upregulated and related to radiosensitivity in cancers. Furthermore, 17 microRNAs and 20 pathways were targeted by different lncRNAs and contributed to the cancer radiotherapy response in this meta-analysis. The individual pooled HRs (95% CIs) of downregulated radiation-resistant and upregulated radiation-resistant lncRNAs for OS were 0.49 (0.40–0.60) and 1.88 (1.26–2.79), respectively. Our results showed that lncRNAs could modulate tumor radioresistance or sensitivity by affecting radiation-related signaling pathways and serve as potential biomarkers to predict radiotherapy response.
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DOI：
10.1016/j.gpb.2015.09.006
发表时间：
2016-02
期刊：
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影响因子：
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DOI：
10.1016/j.omtn.2020.09.020
发表时间：
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期刊：
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影响因子：
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影响因子：
9
作者：
He Y;Jing Y;Wei F;Tang Y;Yang L;Luo J;Yang P;Ni Q;Pang J;Liao Q;Xiong F;Guo C;Xiang B;Li X;Zhou M;Li Y;Xiong W;Zeng Z;Li G
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影响因子：
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